Switch from intravenous to subcutaneous immunoglobulin IgPro20 in CIDP patients: a prospective observational study under real-world conditions.

BACKGROUND

IgPro20 is the first approved subcutaneous immunoglobulin (SCIg) preparation for the treatment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Two different doses of the SCIg preparation were investigated in the pivotal PATH study. Real-world data, and particularly the efficacy of an equivalent dose switch from intravenous immunoglobulin (IVIg) to SCIg, are still not available.

METHODS

In this prospective observational study, 41 patients with CIDP treated with intravenous immunoglobulin (IVIg) were changed to an equivalent (1:1) dose of IgPro20 1 week after last IVIg treatment. Patients were examined at the time of switch from IVIg to SCIg, after 3 and after 6 months and efficacy, treatment preferences and systemic and local reactions were assessed.

RESULTS

Various clinical outcome parameters demonstrated overall stability regarding disability, general activity and social participation, grip and muscle strength, as well as gait impairment. Treatment satisfaction remained unchanged between IVIg and SCIg therapy. However, 88% of patients favoured treatment with subcutaneous IgPro20 over IVIg 6 months after switch to IgPro20.

CONCLUSION

Results demonstrate that the switch of IVIg to an equivalent dose of SCIg represents an effective and preferred treatment option for CIDP patients.

Informations de copyright

© The Author(s), 2021.

Déclaration de conflit d'intérêts

Conflict of interest statement: The authors declare no conflict of interest. Outside the submitted work, the authors received honoraria for lectures, travel grants, or research grants. Stefan Gingele reports research support from Else Kröner Fresenius Stiftung and honoraria for lectures from Merck and Alnylam. Moritz Koch, Anna Christina Saparilla, Gudrun Körner, Jarle von Hörsten, Marina Gingele, Tabea Seeliger, Franz Felix Konen and Martin Hümmert declare that they have no conflict of interest. Alexandra Neyazi reports research support from Internal Funding of the MHH (HiLF) and honoria for lectures from Novartis and Merck. Martin Stangel has received honoraria for scientific lectures or consultancy from Alexion, Bayer Healthcare, Biogen, Celgene, CSL Behring, Grifols, Janssen, Merck-Serono, NeuroTransData, Novartis, Roche, Sanofi Aventis, Takeda, and Teva. His institution received research support from Sanofi Aventis, Novartis and Merck-Serono. Thomas Skripuletz reports research support from Bristol-Myers Squibb, Claudia von Schilling Foundation, Else Kröner Fresenius Stiftung, Hannover Biomedical Research School (HBRS), Sanofi Aventis and honoraria for lectures and travel grants from Alexion, Alnylam, Bayer Vital, Biogen, Celgene, Centogene, CSL Behring, Euroimmun, Merck, Novartis, Roche, Sanofi Aventis, Siemens.