Charting the life course: Emerging opportunities to advance scientific approaches using life course research.
Translational life course research
complexity science
cytomegalovirus
life course and lifespan
life course methods
life course research priorities
Journal
Journal of clinical and translational science
ISSN: 2059-8661
Titre abrégé: J Clin Transl Sci
Pays: England
ID NLM: 101689953
Informations de publication
Date de publication:
15 Jun 2020
15 Jun 2020
Historique:
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
6
5
2021
Statut:
epublish
Résumé
Life course research embraces the complexity of health and disease development, tackling the extensive interactions between genetics and environment. This interdisciplinary blueprint, or theoretical framework, offers a structure for research ideas and specifies relationships between related factors. Traditionally, methodological approaches attempt to reduce the complexity of these dynamic interactions and decompose health into component parts, ignoring the complex reciprocal interaction of factors that shape health over time. New methods that match the epistemological foundation of the life course framework are needed to fully explore adaptive, multilevel, and reciprocal interactions between individuals and their environment. The focus of this article is to (1) delineate the differences between lifespan and life course research, (2) articulate the importance of complex systems science as a methodological framework in the life course research toolbox to guide our research questions, (3) raise key questions that can be asked within the clinical and translational science domain utilizing this framework, and (4) provide recommendations for life course research implementation, charting the way forward. Recent advances in computational analytics, computer science, and data collection could be used to approximate, measure, and analyze the intertwining and dynamic nature of genetic and environmental factors involved in health development.
Identifiants
pubmed: 33948236
doi: 10.1017/cts.2020.492
pii: S2059866120004926
pmc: PMC8057465
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9Subventions
Organisme : NCI NIH HHS
ID : K07 CA230150
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES022832
Pays : United States
Organisme : NCATS NIH HHS
ID : U24 TR002306
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001860
Pays : United States
Informations de copyright
© The Association for Clinical and Translational Science 2020.
Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest.
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