The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma.
BRCA1/2
Endometriosis
methylation profile
next-generation sequencing
ovarian endometrioid carcinoma
Journal
American journal of cancer research
ISSN: 2156-6976
Titre abrégé: Am J Cancer Res
Pays: United States
ID NLM: 101549944
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
01
2021
accepted:
14
02
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
6
5
2021
Statut:
epublish
Résumé
Ovarian cancer is one of the most common cancers worldwide, and is associated with a prior diagnosis of endometriosis in several cases. Our aim was to correlate genetic and methylation profile of ovarian endometrioid ovarian cancer and endometriosis patients. We evaluated the genetic profile of 50 ovarian endometriosis and 20 ovarian endometrioid carcinoma samples using next generation sequencing technology. In addition, the DNA methylation profile was evaluated for both cohorts of patients. We observed several mutated genes that were common for both types of patients, but we also identified mutated genes that were characteristic for each group:
Types de publication
Journal Article
Langues
eng
Pagination
1754-1769Informations de copyright
AJCR Copyright © 2021.
Déclaration de conflit d'intérêts
None.
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