Diagnostic criteria for apathy in neurocognitive disorders.

apathy behavior cognition diagnostic criteria emotion motivation neurocognitive disorder (NCD) neuropsychiatric symptoms (NPS)

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
12 2021
Historique:
revised: 26 03 2021
received: 25 06 2020
accepted: 05 04 2021
pubmed: 6 5 2021
medline: 11 2 2022
entrez: 5 5 2021
Statut: ppublish

Résumé

Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies. These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.

Identifiants

pubmed: 33949763
doi: 10.1002/alz.12358
pmc: PMC8835377
mid: NIHMS1774715
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1892-1904

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : P20 AG068053
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS093334
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109025
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053798
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG059914
Pays : United States

Informations de copyright

© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

David S Miller (DS)

Signant Health, Blue Bell, Pennsylvania, USA.

Philippe Robert (P)

Cognition Behaviour Technology Lab, Université Côte d'Azur, Nice, France.
Association Innovation Alzheimer, Nice, France.
Centre Memoire, Centre Hospitalier Universitaire de Nice, Nice, France.

Larry Ereshefsky (L)

Follow the Molecule, Marina del Rey, California, USA.

Lawrence Adler (L)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Daniel Bateman (D)

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Jeff Cummings (J)

Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, Nevada, USA.
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.

Steven T DeKosky (ST)

Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.

Corinne E Fischer (CE)

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Masud Husain (M)

Department of Experimental Psychology, University of Oxford, Oxford, UK.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Oxford NIHR Biomedical Research Centre, Oxford, UK.

Zahinoor Ismail (Z)

Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Judith Jaeger (J)

CognitionMetrics, Wilmington, Delaware, USA.

Alan J Lerner (AJ)

University Hospitals - Case Western Reserve University, Cleveland, Ohio, USA.

Abby Li (A)

Sunnybrook Research Institute, Toronto, Ontario, Canada.

Constantine G Lyketsos (CG)

Johns Hopkins University, Baltimore, Maryland, USA.

Valeria Manera (V)

Cognition Behaviour Technology Lab, Université Côte d'Azur, Nice, France.
Association Innovation Alzheimer, Nice, France.

Jacobo Mintzer (J)

Medical University of South Carolina and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina, USA.

Hans J Moebius (HJ)

Moebius-Consult, Baar, Switzerland.

Moyra Mortby (M)

UNSW Ageing Futures Institute, The University of New South Wales, Sydney, Australia.

Didier Meulien (D)

Clinical Research and Development, H. Lundbeck A/S, Valby, Denmark.

Stephane Pollentier (S)

Boehringer Ingelheim Pharma GmbH & Co KG, CNS Diseases Research, Biberach an der Riss, Germany.

Anton Porsteinsson (A)

University of Rochester, Rochester, New York, USA.

Jill Rasmussen (J)

Psi-Napse, Dorking, UK.

Paul B Rosenberg (PB)

Johns Hopkins University, Baltimore, Maryland, USA.

Myuri T Ruthirakuhan (MT)

Sunnybrook Research Institute, Toronto, Ontario, Canada.

Mary Sano (M)

Alzheimer Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Carla Zucchero Sarracini (C)

Sunnybrook Research Institute, Toronto, Ontario, Canada.

Krista L Lanctôt (KL)

Sunnybrook Research Institute, Toronto, Ontario, Canada.
Departments of Psychiatry and Pharmacology/Toxicology, University of Toronto, Toronto, Ontario, Canada.

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