Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.
NADPH:disulfide oxidoreductase
allosteric effect
enzyme inhibitor
fragment
schistosomiasis
secondary site
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
09 07 2021
09 07 2021
Historique:
pubmed:
6
5
2021
medline:
3
8
2021
entrez:
5
5
2021
Statut:
ppublish
Résumé
Fragment screening is a powerful drug discovery approach particularly useful for enzymes difficult to inhibit selectively, such as the thiol/selenol-dependent thioredoxin reductases (TrxRs), which are essential and druggable in several infectious diseases. Several known inhibitors are reactive electrophiles targeting the selenocysteine-containing C-terminus and thus often suffering from off-target reactivity
Identifiants
pubmed: 33950676
doi: 10.1021/acsinfecdis.0c00909
pmc: PMC8273128
mid: NIHMS1701403
doi:
Substances chimiques
Antiparasitic Agents
0
Multienzyme Complexes
0
NADH, NADPH Oxidoreductases
EC 1.6.-
thioredoxin glutathione reductase
EC 1.6.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1932-1944Subventions
Organisme : NIAID NIH HHS
ID : R33 AI127635
Pays : United States
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