Epidemiology and factors associated with the severity of viral acute lower respiratory infection in children hospitalized in Manaus, Amazonas, in 2017-2018: An observational study.
Adenoviridae
/ isolation & purification
Adenovirus Infections, Human
/ diagnosis
Brazil
/ epidemiology
Child, Preschool
Coinfection
/ diagnosis
Female
Hospitalization
/ statistics & numerical data
Humans
Incidence
Infant
Infant, Newborn
Influenza, Human
/ diagnosis
Alphainfluenzavirus
/ isolation & purification
Betainfluenzavirus
/ isolation & purification
Male
Metapneumovirus
/ isolation & purification
Paramyxoviridae Infections
/ diagnosis
Respiratory Syncytial Virus Infections
/ diagnosis
Respiratory Syncytial Viruses
/ isolation & purification
Respirovirus
/ isolation & purification
Retrospective Studies
Severity of Illness Index
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
07 May 2021
07 May 2021
Historique:
received:
28
10
2020
accepted:
15
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
21
5
2021
Statut:
ppublish
Résumé
To investigate the epidemiology and factors associated with the severity of viral acute lower respiratory infection (ALRI) in children hospitalized in Manaus, Amazonas, in 2017 to 2018.Retrospective cohort study of children hospitalized at the Hospital and Emergency Room Delphina Rinaldi Abdel Aziz, in Manaus, from April 01, 2017 to August 31, 2018, with a clinical diagnosis of ALRI and nasopharyngeal aspirates positive for at least 1 respiratory virus.One hundred forty-six children aged 0.2 to 66 months (median 7 months) were included. Patients were divided into 2 groups according to the disease severity classified by an adapted Walsh et al score: moderate disease, score 0-4, n = 66 (45.2%) and severe disease, score 5-7, n = 80 (54.8%). A greater number of viral ALRI cases were observed in the rainiest months. Respiratory syncytial virus was the most prevalent (n = 103, 70.3%), followed by metapneumovirus (n = 24, 16.4%), influenza virus (n = 17, 11.6%), parainfluenza virus (n = 11, 7.5%), and adenovirus (n = 4, 2.7%). Co-detections of 2 to 3 viruses were found in 12 (8.2%) patients. The presence of viral coinfection was an independent risk factor for disease severity (adjusted relative risk [RR] 1.53; 95% CI 1.10-2.14). Twelve patients (8.2%) died, all with severe disease. Risk factors for death were shock (adjusted RR 10.09; 95% CI 2.31-43.90) and need for vasoactive drugs (adjusted RR 10.63; 95% CI 2.44-46.31).There was a higher incidence of viral ALRI in Manaus in the rainy season. Respiratory syncytial virus was the most prevalent virus. The presence of viral coinfection was an independent risk factor for disease severity.
Identifiants
pubmed: 33950979
doi: 10.1097/MD.0000000000025799
pii: 00005792-202105070-00067
pmc: PMC8104226
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25799Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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