Breast cancer survival and its prognostic factors in the United Arab Emirates: A retrospective study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
11
2020
accepted:
20
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been studied widely in western populations but are very limited in this region. This study is the first to report breast cancer survival and investigate prognostic factors associated with its survival in the UAE. This is a retrospective cohort study involving 988 patients who were diagnosed and histologically confirmed with breast cancer between January 2008 and December 2012 at Tawam hospital, Al Ain, UAE. Patient were followed from the date of initial diagnosis until the date of death from any cause, lost-to-follow up or the end of December 2018. The primary outcome is overall survival (OS). The Kaplan-Meier method was used to estimate the survival curve along with the 2- and 5-year survivals. Different group of patients categorized according to prognostic factors were compared using the log-rank test. Multiple Cox proportional hazards models was used to examine the impact of several prognostic factors on the overall survival. The median study follow-up was 35 months. Of the 988 patients, 62 had died during their follow-up, 56 were lost to follow-up and 870 were still alive at the end of the study. The average age of patients was 48 years. The majority of patients presented to the hospital with grade II or III, 24% with at least stage 3 and 9.2% had metastasis. The 2-year and 5-year survivals were estimated to 97% and 89% respectively. Results of the multiple Cox proportional hazard model show that tumor grade, and stage of cancer at presentation are jointly significantly associated with survival. The 2- and 5-year survival are within the norms compared to other countries. Significant clinical and pathological prognostic factors associated with survival were tumor grade, and the stage of cancer at presentation.
Sections du résumé
BACKGROUND
Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been studied widely in western populations but are very limited in this region. This study is the first to report breast cancer survival and investigate prognostic factors associated with its survival in the UAE.
METHODS
This is a retrospective cohort study involving 988 patients who were diagnosed and histologically confirmed with breast cancer between January 2008 and December 2012 at Tawam hospital, Al Ain, UAE. Patient were followed from the date of initial diagnosis until the date of death from any cause, lost-to-follow up or the end of December 2018. The primary outcome is overall survival (OS). The Kaplan-Meier method was used to estimate the survival curve along with the 2- and 5-year survivals. Different group of patients categorized according to prognostic factors were compared using the log-rank test. Multiple Cox proportional hazards models was used to examine the impact of several prognostic factors on the overall survival.
RESULTS
The median study follow-up was 35 months. Of the 988 patients, 62 had died during their follow-up, 56 were lost to follow-up and 870 were still alive at the end of the study. The average age of patients was 48 years. The majority of patients presented to the hospital with grade II or III, 24% with at least stage 3 and 9.2% had metastasis. The 2-year and 5-year survivals were estimated to 97% and 89% respectively. Results of the multiple Cox proportional hazard model show that tumor grade, and stage of cancer at presentation are jointly significantly associated with survival.
CONCLUSION
The 2- and 5-year survival are within the norms compared to other countries. Significant clinical and pathological prognostic factors associated with survival were tumor grade, and the stage of cancer at presentation.
Identifiants
pubmed: 33951102
doi: 10.1371/journal.pone.0251118
pii: PONE-D-20-35585
pmc: PMC8099089
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0251118Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
BMJ. 2015 Oct 06;351:h4901
pubmed: 26442924
Int J Surg. 2010;8(6):448-52
pubmed: 20601253
Breast Cancer Res Treat. 2018 Aug;170(3):647-656
pubmed: 29693227
Nat Rev Cancer. 2003 Jun;3(6):453-8
pubmed: 12778135
BMC Bioinformatics. 2008 Jul 11;9:307
pubmed: 18620558
Nat Rev Cancer. 2005 Aug;5(8):591-602
pubmed: 16056258
BMC Public Health. 2013 Oct 09;13:947
pubmed: 24107190
PLoS One. 2014 Sep 29;9(9):e105783
pubmed: 25265385
Lancet. 2015 Mar 14;385(9972):977-1010
pubmed: 25467588
BMC Health Serv Res. 2011 Oct 25;11:284
pubmed: 22027084
JAMA. 2006 Jun 7;295(21):2492-502
pubmed: 16757721
BMC Cancer. 2009 Jun 05;9:168
pubmed: 19497131
Br J Cancer. 2013 Mar 19;108(5):1195-208
pubmed: 23449362
J Natl Cancer Inst Monogr. 1994;(16):69-77
pubmed: 7999472
Lancet. 2011 Oct 22;378(9801):1461-84
pubmed: 21924486