Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney.
chronic kidney disease
fibroblast
fibrosis
myofibroblast
tertiary lymphoid tissue
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
26
03
2021
received:
27
02
2021
accepted:
28
03
2021
pubmed:
6
5
2021
medline:
26
10
2021
entrez:
5
5
2021
Statut:
ppublish
Résumé
Fibroblasts reside in various organs and support tissue structure and homeostasis under physiological conditions. Phenotypic alterations of fibroblasts underlie the development of diverse pathological conditions, including organ fibrosis. Recent advances in single-cell biology have revealed that fibroblasts comprise heterogeneous subpopulations with distinct phenotypes, which exert both beneficial and detrimental effects on the host organs in a context-dependent manner. In the kidney, phenotypic alterations of resident fibroblasts provoke common pathological conditions of chronic kidney disease (CKD), such as renal anemia and peritubular capillary loss. Additionally, in aged injured kidneys, fibroblasts provide functional and structural supports for tertiary lymphoid tissues (TLTs), which serve as the ectopic site of acquired immune reactions in various clinical contexts. TLTs are closely associated with aging and CKD progression, and the developmental stages of TLTs reflect the severity of renal injury. In this review, we describe the current understanding of fibroblast heterogeneity both under physiological and pathological conditions, with special emphasis on fibroblast contribution to TLT formation in the kidney. Dissecting the heterogeneous characteristics of fibroblasts will provide a promising therapeutic option for fibroblast-related pathological conditions, including TLT formation.
Identifiants
pubmed: 33951198
doi: 10.1111/imr.12969
pmc: PMC8360208
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-210Informations de copyright
© 2021 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
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