Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity.
Anti-Bacterial Agents
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Ascorbic Acid
/ chemistry
Bacteria
/ drug effects
Cell Line, Tumor
Coordination Complexes
/ chemical synthesis
Copper
/ chemistry
Drug Screening Assays, Antitumor
Estrone
/ analogs & derivatives
Gallium
/ chemistry
Glutathione
/ chemistry
Humans
Ligands
Molecular Structure
Reactive Oxygen Species
/ metabolism
Semicarbazones
/ chemical synthesis
Antibacterial
Hybrid molecules
Semicarbazones
Solution stability
X-ray crystal structure
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
16
03
2021
revised:
08
04
2021
accepted:
18
04
2021
pubmed:
6
5
2021
medline:
9
2
2022
entrez:
5
5
2021
Statut:
ppublish
Résumé
The solution chemical properties such as proton dissociation, complex formation with copper(II) and gallium(III) ions in addition to antibacterial and antitumor activity of a novel tridentate salicyaldehyde semicarbazone-estrone hybrid (estrone-SC) and a related bicyclic compound (thn-SC) were investigated. The crystal structure of complex [Cu(thn-SCH
Identifiants
pubmed: 33951554
pii: S0162-0134(21)00115-X
doi: 10.1016/j.jinorgbio.2021.111468
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents
0
Coordination Complexes
0
Ligands
0
Reactive Oxygen Species
0
Semicarbazones
0
Estrone
2DI9HA706A
Copper
789U1901C5
Gallium
CH46OC8YV4
Glutathione
GAN16C9B8O
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111468Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.