Predicting risk of erectile dysfunction in patients with nonalcoholic fatty liver disease.
IIEF-5
erectile dysfunction
hepatosteatosis
impotence
nonalcoholic fatty liver disease
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
12
04
2021
received:
29
03
2021
accepted:
17
04
2021
pubmed:
6
5
2021
medline:
9
7
2021
entrez:
5
5
2021
Statut:
ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is one of the risk factors for erectile dysfunction (ED). We aimed to predict the risk of ED in patients with NAFLD. The study included 146 male patients complaining impotence admitted to the urology outpatient clinic aged 24-80 years without a history of alcohol use who underwent abdominal ultrasonography between February 2018 and January 2019. 106 patients with NAFLD and 40 men without NAFLD were included in the study. Clinical and laboratory parameters, ED status according to International Index of Erectile Function-5 were compared between patients with and without NAFLD. The mean age of patients was 51.47 ± 10.34 years. NAFLD was detected in 72.6% of the patients. No statistically significant difference was found regarding mean age, BMI, IIEF-5 scores, DM status, serum glucose levels (p > .05). Fasting insulin levels, hypertension (HT), insulin resistance (IR) and ED status of the patients with NAFLD were significantly higher than patients without NAFLD (p < .05). NAFLD was found to be a significantly independent associated with ED. We also found that patients with NAFLD have risk of ED 2.92 times higher than without NAFLD (OR: 2.92). For the patients presenting with erectile dysfunction, hepatic steatosis should also be considered.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14091Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Besiroglu, H., Otunctemur, A., & Ozbek, E. (2015). The relationship between metabolic syndrome, its components, and erectile dysfunction: A systematic review and a meta-analysis of observational studies. The Journal of Sexual Medicine, 12(6), 1309-1318. https://doi.org/10.1111/jsm.12885
Burnett, A. L., Lowenstein, C. J., Bredt, D. S., Chang, T. S., & Snyder, S. H. (1992). Nitric oxide: A physiologic mediator of penile erection. Science, 257(5068), 401-403. https://doi.org/10.1126/science.1378650
Burra, P., Germani, G., Masier, A., De Martin, E., Gambato, M., Salonia, A., Bo, P., Vitale, A., Cillo, U., Russo, F. P., & Senzolo, M. (2010). Sexual dysfunction in chronic liver disease: Is liver transplantation an effective cure? Transplantation, 89(12), 1425-1429. https://doi.org/10.1097/TP.0b013e3181e1f1f6
Contreras, C., Sánchez, A., Martínez, P., Climent, B., Benedito, S., García-Sacristán, A., Hernández, M., & Prieto, D. (2013). Impaired endothelin calcium signaling coupled to endothelin type B receptors in penile arteries from insulin-resistant obese Zucker rats. The Journal of Sexual Medicine, 10(9), 2141-2153. https://doi.org/10.1111/jsm.12234
Duman, D. G., Biçakci, E., Çelikel, Ç. A., & Akbal, C. (2016). Nonalcoholic fatty liver disease is associated with erectile dysfunction: A prospective pilot study. The Journal of Sexual Medicine, 13(3), 383-388. https://doi.org/10.1016/j.jsxm.2015.12.030
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001). Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA: The Journal of the American Medical Association, 285(19), 2486-2497. https://doi.org/10.1001/jama.285.19.2486
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994). Impotence and its medical and psychosocial correlates: Results of the Massachusetts male aging study. Journal of Urology, 151(1), 54-61. https://doi.org/10.1016/s0022-5347(17)34871-1
Gratzke, C., Angulo, J., Chitaley, K., Dai, Y.-T., Kim, N. N., Paick, J.-S., Simonsen, U., Ückert, S., Wespes, E., Andersson, K. E., Lue, T. F., & Stief, C. G. (2010). Anatomy, physiology, and pathophysiology of erectile dysfunction. The Journal of Sexual Medicine, 7(1 Pt 2), 445-475. https://doi.org/10.1111/j.1743-6109.2009.01624.x
Hamaguchi, M., Kojima, T., Itoh, Y., Harano, Y., Fujii, K., Nakajima, T., Kato, T., Takeda, N., Okuda, J., Ida, K., Kawahito, Y., Yoshikawa, T., & Okanoue, T. (2007). The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. American Journal of Gastroenterology, 102(12), 2708-2715. https://doi.org/10.1111/j.1572-0241.2007.01526.x
Hasanain, A. F. A., Mahdy, R. E., Mahran, A. M. A., Safwat, A. S. M., Mohamed, A. O., & Abdel-Aal, S. M. (2017). Erectile dysfunction in patients with nonalcoholic fatty liver disease. Arab Journal of Gastroenterology, 18(1), 21-24. https://doi.org/10.1016/j.ajg.2017.02.002
Hawksworth, D. J., & Burnett, A. L. (2020). Nonalcoholic fatty liver disease, male sexual dysfunction, and infertility: Common links, common problems. Sexual Medicine Reviews, 8(2), 274-285. https://doi.org/10.1016/j.sxmr.2019.01.002
Hernaez, R., Lazo, M., Bonekamp, S., Kamel, I., Brancati, F. L., Guallar, E., & Clark, J. M. (2011). Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis. Hepatology, 54(3), 1082-1090. https://doi.org/10.1002/hep.24452
Iqbal, U., Perumpail, B. J., Akhtar, D., Kim, D., & Ahmed, A. (2019). The epidemiology, risk profiling and diagnostic challenges of nonalcoholic fatty liver disease. Medicines (Basel), 6(1), 41. https://doi.org/10.3390/medicines6010041
Kelly, D. M., Nettleship, J. E., Akhtar, S., Muraleedharan, V., Sellers, D. J., Brooke, J. C., McLaren, D. S., Channer, K. S., & Jones, T. H. (2014). Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice. Life Sciences, 109(2), 95-103. https://doi.org/10.1016/j.lfs.2014.06.007
Kim, S., Kwon, H., Park, J.-H., Cho, B., Kim, D., Oh, S.-W., Lee, C. M., & Choi, H.-C. (2012). A low level of serum total testosterone is independently associated with nonalcoholic fatty liver disease. BMC Gastroenterology, 12, 69. https://doi.org/10.1186/1471-230x-12-69
Machado, M. V., & Cortez-Pinto, H. (2014). Non-alcoholic fatty liver disease: What the clinician needs to know. World Journal of Gastroenterology, 20(36), 12956-12980. https://doi.org/10.3748/wjg.v20.i36.12956
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412-419. https://doi.org/10.1007/bf00280883
Milić, S., & Stimac, D. (2012). Nonalcoholic fatty liver disease/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment. Digestive Diseases, 30(2), 158-162. https://doi.org/10.1159/000336669
NIH consensus conference (1993). Impotence. NIH consensus development panel on impotence. JAMA, 270(1), 83-90.
Nozaki, Y., Fujita, K., Wada, K., Yoneda, M., Shinohara, Y., Imajo, K., Ogawa, Y., Kessoku, T., Nakamuta, M., Saito, S., Masaki, N., Nagashima, Y., Terauchi, Y., & Nakajima, A. (2015). Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution. BMC Gastroenterology, 15, 177. https://doi.org/10.1186/s12876-015-0409-9
Patel, J. P., Lee, E. H., Mena, C. I., & Walker, C. N. (2017). Effects of metformin on endothelial health and erectile dysfunction. Translational Andrology and Urology, 6(3), 556-565. https://doi.org/10.21037/tau.2017.03.52
Persico, M., Masarone, M., Damato, A., Ambrosio, M., Federico, A., Rosato, V., Bucci, T., Carrizzo, A., & Vecchione, C. (2017). Correction to: "Non alcoholic fatty liver disease and eNOS dysfunction in humans". BMC Gastroenterology, 17(1), 116. https://doi.org/10.1186/s12876-017-0671-0
Saadeh, S., Younossi, Z. M., Remer, E. M., Gramlich, T., Ong, J. P., Hurley, M., Mullen, K. D., Cooper, J. N., & Sheridan, M. J. (2002). The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology, 123(3), 745-750. https://doi.org/10.1053/gast.2002.35354
Salonia, A., Bettochi, C., Carvalho, J., Corona, G., Jones, T. H., Kadioğlu, A., & Verze, P. (2020). EAU Guidelines on Sexual and Reproductive Health 2020. In European association of urology guidelines. 2020 Edition. (Vol. presented at the EAU Annual Congress Amsterdam 2020). European Association of Urology Guidelines Office.
Sanyal, A. J. (2019). Past, present and future perspectives in nonalcoholic fatty liver disease. Nature Reviews Gastroenterology & Hepatology, 16(6), 377-386. https://doi.org/10.1038/s41575-019-0144-8
Simental-Mendía, L. E., Simental-Mendía, E., Rodríguez-Hernández, H., Rodríguez-Morán, M., & Guerrero-Romero, F. (2016). The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women. Annals of Hepatology, 15(5), 715-720. https://doi.org/10.5604/16652681.1212431
Turunç, T., Deveci, S., Güvel, S., & Peşkircioğlu, L. (2007). The assessment of Turkish validation with 5 question version of international index of erectile function (IIEF-5). Turkish Journal of Urology, 33(1), 45-49.
Vignozzi, L., Filippi, S., Comeglio, P., Cellai, I., Sarchielli, E., Morelli, A., Rastrelli, G., Maneschi, E., Galli, A., Vannelli, G. B., Saad, F., Mannucci, E., Adorini, L., & Maggi, M. (2014). Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: An experimental study in the rabbit. Molecular and Cellular Endocrinology, 384(1-2), 143-154. https://doi.org/10.1016/j.mce.2014.01.014
Völzke, H., Aumann, N., Krebs, A., Nauck, M., Steveling, A., Lerch, M. M., Rosskopf, D., & Wallaschofski, H. (2010). Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men. International Journal of Andrology, 33(1), 45-53. https://doi.org/10.1111/j.1365-2605.2009.00953.x
Yilmaz, M., Karaaslan, M., Tonyali, S., Celik, M., Toprak, T., & Odabas, O. (2021). Triglyceride-glucose index (TyG) is associated with erectile dysfunction: A cross-sectional study. Andrology, 9(1), 238-244. https://doi.org/10.1111/andr.12904