Additive Effect of Coexisting Aneurysms Increases Subarachnoid Hemorrhage Risk in Patients With Multiple Aneurysms.

Aneurysm, Ruptured / diagnostic imaging Cross-Sectional Studies Female Humans Intracranial Aneurysm / diagnostic imaging Male Risk Factors Subarachnoid Hemorrhage / diagnostic imaging
intracranial aneurysm patients risk factors rupture subarachnoid hemorrhage

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 7 5 2021
medline: 5 1 2022
entrez: 6 5 2021
Statut: ppublish

Résumé

It remains unclear whether the additive effect of coexisting intracranial aneurysms increases the risk of subarachnoid hemorrhage (SAH) in patients with multiple intracranial aneurysms. We have performed a tentative analysis for the additive effect of coexisting aneurysms. This multi-institutional cross-sectional study included 1781 aneurysms from 746 patients with multiple intracranial aneurysms. Using the generalized linear mixed model, we analyzed risk factors associated with individual aneurysm rupture and assessed the additive risk of SAH for each patient. The coexisting aneurysms number was not significantly associated with individual intracranial aneurysm rupture, both in unadjusted and adjusted analyses. Patient-level analysis found that an increased number of coexisting aneurysms was significantly associated with a greater estimated additive risk ( We found that a greater number of coexisting aneurysms did not increase rupture risk of individual aneurysms, but the potential additive effect might increase SAH risk in patients with multiple intracranial aneurysms.

Sections du résumé

BACKGROUND AND PURPOSE
It remains unclear whether the additive effect of coexisting intracranial aneurysms increases the risk of subarachnoid hemorrhage (SAH) in patients with multiple intracranial aneurysms. We have performed a tentative analysis for the additive effect of coexisting aneurysms.
METHODS
This multi-institutional cross-sectional study included 1781 aneurysms from 746 patients with multiple intracranial aneurysms. Using the generalized linear mixed model, we analyzed risk factors associated with individual aneurysm rupture and assessed the additive risk of SAH for each patient.
RESULTS
The coexisting aneurysms number was not significantly associated with individual intracranial aneurysm rupture, both in unadjusted and adjusted analyses. Patient-level analysis found that an increased number of coexisting aneurysms was significantly associated with a greater estimated additive risk (
CONCLUSIONS
We found that a greater number of coexisting aneurysms did not increase rupture risk of individual aneurysms, but the potential additive effect might increase SAH risk in patients with multiple intracranial aneurysms.

Identifiants

DOI: 10.1161/STROKEAHA.120.032500 PMID: 33951928
pubmed: 33951928
doi: 10.1161/STROKEAHA.120.032500
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2418-2421

Auteurs

Xin Feng (X)

Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China (X.F., P.Q., J.L., D.W.).
Graduate School of Peking Union Medical College, Beijing, China (X.F., P.Q., J.L., D.W.).

Xin Tong (X)

Beijing Neurosurgical Institute (X.T., F.P., H.N., Z.W., A.L.), Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).

Fei Peng (F)

Beijing Neurosurgical Institute (X.T., F.P., H.N., Z.W., A.L.), Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).

Hao Niu (H)

Beijing Neurosurgical Institute (X.T., F.P., H.N., Z.W., A.L.), Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).

Peng Qi (P)

Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China (X.F., P.Q., J.L., D.W.).
Graduate School of Peking Union Medical College, Beijing, China (X.F., P.Q., J.L., D.W.).

Jun Lu (J)

Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China (X.F., P.Q., J.L., D.W.).
Graduate School of Peking Union Medical College, Beijing, China (X.F., P.Q., J.L., D.W.).

Yang Zhao (Y)

Department of Interventional Neuroradiology, Beijing Chaoyang Hospital (Yang Zhao, W.J., H.L.), Capital Medical University, China.

Weitao Jin (W)

Department of Interventional Neuroradiology, Beijing Chaoyang Hospital (Yang Zhao, W.J., H.L.), Capital Medical University, China.

Zhongxue Wu (Z)

Beijing Neurosurgical Institute (X.T., F.P., H.N., Z.W., A.L.), Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).

He Liu (H)

Department of Interventional Neuroradiology, Beijing Chaoyang Hospital (Yang Zhao, W.J., H.L.), Capital Medical University, China.

Yuanli Zhao (Y)

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).
Department of Neurosurgery, Peking University International Hospital, Beijing, China (Yuanli Zhao).

Aihua Liu (A)

Beijing Neurosurgical Institute (X.T., F.P., H.N., Z.W., A.L.), Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China (X.T., F.P., H.N., Z.W., Yuanli Zhao, A.L.).

Daming Wang (D)

Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China (X.F., P.Q., J.L., D.W.).
Graduate School of Peking Union Medical College, Beijing, China (X.F., P.Q., J.L., D.W.).

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Anévrysme › Rupture d'anévrysme › Additive Effect of Coexisting Aneurysms...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Additive Effect of Coexisting Aneurysms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Additive Effect of Coexisting Aneurysms...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Artériopathies intracrâniennes › Anévrysme intracrânien › Additive Effect of Coexisting Aneurysms...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Additive Effect of Coexisting Aneurysms...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie meningée › Additive Effect of Coexisting Aneurysms...