Adaptive Radiation Therapy for Intact Thymoma: An Illustrative Report.
Adaptive radiation therapy
WHO Type B2 thymoma
induction chemoradiation
intact thymoma
radiosensitive malignancy
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
17
03
2021
revised:
28
03
2021
accepted:
16
04
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
14
5
2021
Statut:
ppublish
Résumé
Adaptive radiation therapy (ART) is a technique capable of reducing radiation dose to normal tissue without compromising local control. For potentially resectable thymoma, induction therapy is standard of care. Because large disease volume is common in this context, ART has been suggested to reduce toxicity from induction chemoradiation. This has not been previously illustrated in the literature. A 38-year-old man with initially unresectable thymoma was treated with induction chemoradiation including cisplatin and etoposide. He received 45 Gy in 25 fractions and ART was utilized to shrink the radiotherapy field for the final 10 fractions. Thymectomy showed Masaoka stage III disease with negative margins. He experienced no treatment-related toxicity and has no evidence of disease 8 years after diagnosis. Induction chemoradiotherapy with ART appears to be feasible, safe, and efficacious for locally advanced intact thymoma.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Adaptive radiation therapy (ART) is a technique capable of reducing radiation dose to normal tissue without compromising local control. For potentially resectable thymoma, induction therapy is standard of care. Because large disease volume is common in this context, ART has been suggested to reduce toxicity from induction chemoradiation. This has not been previously illustrated in the literature.
CASE REPORT
METHODS
A 38-year-old man with initially unresectable thymoma was treated with induction chemoradiation including cisplatin and etoposide. He received 45 Gy in 25 fractions and ART was utilized to shrink the radiotherapy field for the final 10 fractions.
RESULTS
RESULTS
Thymectomy showed Masaoka stage III disease with negative margins. He experienced no treatment-related toxicity and has no evidence of disease 8 years after diagnosis.
CONCLUSION
CONCLUSIONS
Induction chemoradiotherapy with ART appears to be feasible, safe, and efficacious for locally advanced intact thymoma.
Identifiants
pubmed: 33952472
pii: 41/5/2467
doi: 10.21873/anticanres.15022
doi:
Substances chimiques
Etoposide
6PLQ3CP4P3
Cisplatin
Q20Q21Q62J
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2467-2471Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.