Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery.
Single-isocenter
brain metastasis
contrast-enhanced magnetic resonance imaging
dynamic conformal arc
lung cancer
stereotactic radiosurgery
tumor quantification
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
31
03
2021
revised:
15
04
2021
accepted:
16
04
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
14
5
2021
Statut:
ppublish
Résumé
Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice. Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy. Based on tumor reduction rates (TRRs) measured before and after SIMT SRS, tumor shrinkage effect was categorized into four grades; almost disappeared: TRR=1, decreased: 0.3≤TRR<1, stable: -0.2<TRR<0.3 and increased: TRR≤-0.2. Tumor shrinkage effects were compared among 3 groups; near group with a distance of <3.2 cm, middle group with a distance of ≥3.2 cm and <6.4 cm, and far group with a distance of ≥6.4 cm, categorized by distance from the isocenter. Median survival time was 17 months, with 63.7%, 11.5% and 12.4% of metastases corresponded to almost disappeared, decreased and stable, respectively. No significant difference was found in the distribution for TRRs among 3 groups. Good local control of multiple brain metastases was demonstrated by SIMT SRS, irrespective of distance from the isocenter.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice.
PATIENTS AND METHODS
METHODS
Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy. Based on tumor reduction rates (TRRs) measured before and after SIMT SRS, tumor shrinkage effect was categorized into four grades; almost disappeared: TRR=1, decreased: 0.3≤TRR<1, stable: -0.2<TRR<0.3 and increased: TRR≤-0.2. Tumor shrinkage effects were compared among 3 groups; near group with a distance of <3.2 cm, middle group with a distance of ≥3.2 cm and <6.4 cm, and far group with a distance of ≥6.4 cm, categorized by distance from the isocenter.
RESULTS
RESULTS
Median survival time was 17 months, with 63.7%, 11.5% and 12.4% of metastases corresponded to almost disappeared, decreased and stable, respectively. No significant difference was found in the distribution for TRRs among 3 groups.
CONCLUSION
CONCLUSIONS
Good local control of multiple brain metastases was demonstrated by SIMT SRS, irrespective of distance from the isocenter.
Identifiants
pubmed: 33952486
pii: 41/5/2575
doi: 10.21873/anticanres.15036
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2575-2581Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.