Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain.

Aging / drug effects Animals Atrophy / pathology Brain / drug effects Calcineurin Inhibitors / pharmacology Dogs Female Male Tacrolimus / pharmacology
Alzheimer's disease aging calcineurin canine diffusion-weighted imaging neuroinflammation

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
09 06 2021
Historique:
received: 12 02 2021
revised: 09 04 2021
accepted: 16 04 2021
pubmed: 7 5 2021
medline: 20 11 2021
entrez: 6 5 2021
Statut: ppublish

Résumé

The overexpression of calcineurin leads to astrocyte hyperactivation, neuronal death, and inflammation, which are characteristics often associated with pathologic aging and Alzheimer's disease. In this study, we tested the hypothesis that tacrolimus, a calcineurin inhibitor, prevents age-associated microstructural atrophy, which we measured using higher-order diffusion MRI, in the middle-aged beagle brain (

Identifiants

DOI: 10.1523/JNEUROSCI.0361-21.2021 PMID: 33952632 PMC: PMC8197636
pubmed: 33952632
pii: JNEUROSCI.0361-21.2021
doi: 10.1523/JNEUROSCI.0361-21.2021
pmc: PMC8197636
doi:

Substances chimiques

Calcineurin Inhibitors 0
Tacrolimus WM0HAQ4WNM

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5124-5133

Subventions

Organisme : NIA NIH HHS
ID : R01 AG056998
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056998
Pays : United States

Informations de copyright

Copyright © 2021 the authors.

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Auteurs

Hamsanandini Radhakrishnan (H)

Mathematical, Computational and Systems Biology, University of California, Irvine, Irvine, California 92697.

Margo F Ubele (MF)

Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky 40506.

Stephanie M Krumholz (SM)

Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky 40506.

Kathy Boaz (K)

Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky 40506.

Jennifer L Mefford (JL)

Division of Laboratory Animal Resources, University of Kentucky, Lexington, Kentucky 40506.

Erin Denhart Jones (ED)

Division of Laboratory Animal Resources, University of Kentucky, Lexington, Kentucky 40506.

Beverly Meacham (B)

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky 40506.

Jeffrey Smiley (J)

Division of Laboratory Animal Resources, University of Kentucky, Lexington, Kentucky 40506.

László G Puskás (LG)

Aperus Pharma, H-6726, Szeged, Hungary.

David K Powell (DK)

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky 40506.

Christopher M Norris (CM)

Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky 40506.

Craig E L Stark (CEL)

Mathematical, Computational and Systems Biology, University of California, Irvine, Irvine, California 92697.
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.

Elizabeth Head (E)

Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, California 92697 heade@uci.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › Eucaryotes › Animaux › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la calcineurine › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Tacrolimus Protects against Age-Associated...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tacrolimus › Tacrolimus Protects against Age-Associated...