Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
05 May 2021
05 May 2021
Historique:
received:
06
08
2020
accepted:
15
03
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
7
5
2021
Statut:
aheadofprint
Résumé
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and Higher MeDi adherence related to larger mediotemporal gray matter volume (p<0.05 FWE corrected), better memory (β±SE = 0.03 ± 0.02; p=0.038), and less amyloid (Aβ42/40 ratio, β±SE = 0.003 ± 0.001; p=0.008) and pTau181 pathology (β±SE = -1.96±0.68; p=0.004). Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations between Aβ42/40 ratio, pTau181 and mediotemporal atrophy. Results were consistent correcting for ApoE-ε4 status. Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. Importantly, they suggest that these associations might be explained by a decrease of amyloidosis and tau-pathology. Longitudinal and dietary intervention studies should further examine this conjecture and its treatment implications.
Identifiants
pubmed: 33952652
pii: WNL.0000000000012067
doi: 10.1212/WNL.0000000000012067
pmc: PMC8253566
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021 American Academy of Neurology.
Références
J Nutr Biochem. 2015 Dec;26(12):1479-90
pubmed: 26344778
Alzheimers Dement. 2014 Nov;10(6):844-52
pubmed: 24798886
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Transl Psychiatry. 2018 Oct 30;8(1):238
pubmed: 30375373
JAMA. 2009 Aug 12;302(6):627-37
pubmed: 19671904
J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):318-326
pubmed: 29244059
J Alzheimers Dis. 2017;57(4):1105-1121
pubmed: 28059794
Am J Med. 2018 Nov;131(11):1372-1381.e4
pubmed: 30056104
Alzheimers Dement. 2015 Sep;11(9):1023-31
pubmed: 26190494
Alzheimers Dement. 2017 Mar;13(3):296-311
pubmed: 27825022
PLoS One. 2017 Aug 1;12(8):e0182048
pubmed: 28763509
JAMA Intern Med. 2015 Jul;175(7):1094-1103
pubmed: 25961184
Adv Nutr. 2017 Jul 14;8(4):571-586
pubmed: 28710144
N Engl J Med. 2003 Jun 26;348(26):2599-608
pubmed: 12826634
J Nutr. 2003 Feb;133(2):510-5
pubmed: 12566492
Am J Geriatr Psychiatry. 2016 Sep;24(9):729-37
pubmed: 27421618
Arch Neurol. 2009 Feb;66(2):216-25
pubmed: 19204158
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Alzheimers Dement (N Y). 2018 Sep 06;4:575-590
pubmed: 30406177
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Epidemiology. 2013 Jul;24(4):479-89
pubmed: 23680940
Neurology. 2018 May 15;90(20):e1789-e1798
pubmed: 29653991
Eur J Clin Nutr. 2018 Jan;72(1):30-43
pubmed: 28488692
J Prev Alzheimers Dis. 2014 Jun;1(1):23-32
pubmed: 25237654
J Alzheimers Dis. 2014;39(2):271-82
pubmed: 24164735
BMJ. 2008 Sep 11;337:a1344
pubmed: 18786971
Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84
pubmed: 7566337
J Clin Epidemiol. 1993 Feb;46(2):153-62
pubmed: 8437031
Alzheimers Dement. 2017 Feb;13(2):168-177
pubmed: 27461490
J Nutr Health Aging. 2013;17(6):544-52
pubmed: 23732551
Adv Nutr. 2016 Sep 15;7(5):889-904
pubmed: 27633105
Eur J Nutr. 2021 Mar;60(2):849-860
pubmed: 32472387
Adv J Mol Imaging. 2014 Oct;4(4):43-57
pubmed: 25599008
J Alzheimers Dis. 2018;64(1):281-290
pubmed: 29889074
Am J Epidemiol. 2020 Apr 2;189(4):305-313
pubmed: 31781745
J Neurochem. 2007 May;101(4):1053-9
pubmed: 17254013
Public Health Nutr. 2008 Oct;11(10):1054-62
pubmed: 18205988
Neurology. 2015 Nov 17;85(20):1744-51
pubmed: 26491085
Exp Gerontol. 2013 Dec;48(12):1443-8
pubmed: 24126083
Ann Neurol. 2006 Jun;59(6):912-21
pubmed: 16622828
Am J Clin Nutr. 2019 Feb 1;109(2):361-368
pubmed: 30698630
Nat Commun. 2020 Mar 13;11(1):1377
pubmed: 32170138
J Prev Alzheimers Dis. 2018;5(2):137-141
pubmed: 29616707
Epidemiology. 2013 Jul;24(4):490-9
pubmed: 23676264
Alzheimers Dement. 2020 Sep;16(9):1305-1311
pubmed: 30222945
Neurology. 2020 Sep 1;95(9):e1134-e1143
pubmed: 32636322
Adv Nutr. 2015 Mar 13;6(2):154-68
pubmed: 25770254
Nutrients. 2019 Jan 21;11(1):
pubmed: 30669673
Alzheimers Res Ther. 2018 Feb 07;10(1):15
pubmed: 29415768