Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults: A Registry-Based Study.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
05 May 2021
05 May 2021
Historique:
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
7
5
2021
Statut:
aheadofprint
Résumé
Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. This study aims is to investigate the links between kidney function, kidney function decline and dementia incidence. We analyzed the association of eGFR with the risk of dementia (defined as a new dementia diagnosis or initiation of dementia treatments) among 329,822 residents of Stockholm who accessed healthcare during 2006-2011, were ≥65 years, had no history of dementia or underwent kidney replacement therapy. We also estimated the rate of eGFR decline among 205,622 residents with repeated eGFR measurements during the first-year of observation and investigated its association with subsequent dementia risk. 18,983 cases of dementia (5.8% of participants) were detected over a median follow-up of 5 years. Dementia incidence rates (IR) were progressively higher with lower eGFR: from 6.56/1000 person-years in persons with eGFR 90-104ml/min to 30.28/1000 person-years in those with eGFR<30ml/min. After multivariable adjustment, lower eGFR was associated with a higher dementia risk [hazard ratio(HR), 1.71; 95% confidence interval(CI), 1.54-1.91 in eGFR 30-59ml/min and HR 2.62, 1.91-3.58 in eGFR<30ml/min] compared with eGFR of 90-104ml/min. A steeper decline in eGFR (decline>2ml/min/1.73m Both lower kidney function and steeper kidney function decline are associated with the development of dementia.
Identifiants
pubmed: 33952656
pii: WNL.0000000000012113
doi: 10.1212/WNL.0000000000012113
pmc: PMC8253567
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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