Cortisol modulates calcium release-activated calcium channel gating in fish hepatocytes.
Animals
Calcium
/ metabolism
Calcium Release Activated Calcium Channels
/ metabolism
Calcium Signaling
/ drug effects
Corticosterone
/ pharmacology
Enzyme Inhibitors
/ pharmacology
Estradiol
/ pharmacology
Hepatocytes
/ drug effects
Hydrocortisone
/ pharmacology
Ion Channel Gating
/ drug effects
Oncorhynchus mykiss
Testosterone
/ pharmacology
Thapsigargin
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 05 2021
05 05 2021
Historique:
received:
04
11
2020
accepted:
12
04
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Glucocorticoids (GCs) are rapidly released in response to stress and play an important role in the physiological adjustments to re-establish homeostasis. The mode of action of GCs for stress coping is mediated largely by the steroid binding to the glucocorticoid receptor (GR), a ligand-bound transcription factor, and modulating the expression of target genes. However, GCs also exert rapid actions that are independent of transcriptional regulation by modulating second messenger signaling. However, a membrane-specific protein that transduces rapid GCs signal is yet to be characterized. Here, using freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and fura2 fluorescence microscopy, we report that stressed levels of cortisol rapidly stimulate the rise in cytosolic free calcium ([Ca
Identifiants
pubmed: 33953236
doi: 10.1038/s41598-021-88957-3
pii: 10.1038/s41598-021-88957-3
pmc: PMC8100157
doi:
Substances chimiques
Calcium Release Activated Calcium Channels
0
Enzyme Inhibitors
0
Testosterone
3XMK78S47O
Estradiol
4TI98Z838E
Thapsigargin
67526-95-8
Calcium
SY7Q814VUP
Corticosterone
W980KJ009P
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9621Références
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