Definitive Radiotherapy for Penoscrotal Extramammary Paget's Disease: A Case Report with Long-Term Follow-Up.
80 and over
Paget disease
Radiotherapy
aged
extramammary
skin neoplasms
Journal
Clinical medicine insights. Case reports
ISSN: 1179-5476
Titre abrégé: Clin Med Insights Case Rep
Pays: United States
ID NLM: 101531893
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
02
2021
accepted:
22
03
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
7
5
2021
Statut:
epublish
Résumé
Penoscrotal extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma in older male patients, and no effective nonsurgical treatment strategies are currently available. The aim of this study was to report the usefulness of external radiotherapy (RT) for penoscrotal EMPD in an inoperable elderly patient. This report presents the treatment of an 89-year-old man with widespread penoscrotal EMPD. A multidisciplinary treatment team decided on radical RT. The patient received a radiation dose of 61.8 Gy in 30 fractions through electron and photon beams. His treatment tolerance was good, and no severe toxicity had been observed up the last follow-up. At 6.5 years after the RT, the patient showed no evidence of recurrence. Definitive RT resulted in excellent disease control and minimal toxicity; thus, it could be a promising nonsurgical therapeutic option for penoscrotal EMPD, even in extremely elderly individuals.
Identifiants
pubmed: 33953632
doi: 10.1177/11795476211009251
pii: 10.1177_11795476211009251
pmc: PMC8042548
doi:
Types de publication
Case Reports
Langues
eng
Pagination
11795476211009251Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Dermatol Ther. 2020 Nov;33(6):e13890
pubmed: 32584449
Cochrane Database Syst Rev. 2019 Jun 05;6:CD009245
pubmed: 31167037
BMC Cancer. 2016 Jul 29;16:563
pubmed: 27473174
Dermatol Clin. 2010 Oct;28(4):807-26
pubmed: 20883922
J Eur Acad Dermatol Venereol. 2007 May;21(5):581-90
pubmed: 17447970
Gynecol Oncol Rep. 2020 Nov 12;34:100674
pubmed: 33251315
Int J Dermatol. 2019 Aug;58(8):871-879
pubmed: 30569580
Int J Gynecol Cancer. 2018 May;28(4):829-839
pubmed: 29538255
Cureus. 2019 Oct 17;11(10):e5937
pubmed: 31788394
Dermatology. 2020;236(6):493-499
pubmed: 32289785
JAAD Case Rep. 2018 Dec 09;5(1):72-74
pubmed: 30560191