The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis.
Amyotrophic Lateral Sclerosis
/ etiology
Case-Control Studies
Computational Biology
Gene Expression Regulation
Gene Ontology
Gene Regulatory Networks
Humans
MicroRNAs
/ genetics
Protein Interaction Maps
/ genetics
Protein Serine-Threonine Kinases
/ genetics
RNA, Long Noncoding
/ genetics
RNA, Messenger
/ genetics
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
01
2021
revised:
02
03
2021
accepted:
05
03
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
25
9
2021
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily affects motor neurons, causing muscle atrophy, bulbar palsy, and pyramidal tract signs. However, the aetiology and pathogenesis of ALS have not been elucidated to date. In this study, a competitive endogenous RNA (ceRNA) network was constructed by analyzing the expression profiles of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that were matched by 7 ALS samples and 4 control samples, and then a protein-protein interaction (PPI) network was constructed to identify the genes related to ALS. Gene Ontology (GO) was used to study the potential functions of differentially expressed mRNAs (DEmRNAs) in the ceRNA network. For the ALS and control groups, 247177 potential lncRNA-mRNA ceRNA relationship pairs were screened. Analysis of significant relationship pairs demonstrated that the PPI modules formed by the
Identifiants
pubmed: 33953791
doi: 10.1155/2021/5526179
pmc: PMC8067776
doi:
Substances chimiques
MALAT1 long non-coding RNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
RNA, Messenger
0
AAK1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5526179Informations de copyright
Copyright © 2021 Dingsheng Liu et al.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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