Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.

Child Humans Hypoxia / etiology Kenya Oxygen Oxygen Inhalation Therapy Pneumonia / complications

African children Clinical trial High-flow nasal therapy Oxygen Pneumonia

Journal

Intensive care medicine

ISSN: 1432-1238

Titre abrégé: Intensive Care Med

Pays: United States

ID NLM: 7704851

Informations de publication

Date de publication:
05 2021

Historique:

received: 11 02 2021

accepted: 15 03 2021

pubmed: 7 5 2021

medline: 9 6 2021

entrez: 6 5 2021

Statut: ppublish

Résumé

The life-saving role of oxygen therapy in African children with severe pneumonia is not yet established. The open-label fractional-factorial COAST trial randomised eligible Ugandan and Kenyan children aged > 28 days with severe pneumonia and severe hypoxaemia stratum (SpO The trial was stopped early after enrolling 1852/4200 children, including 388 in the severe hypoxaemia stratum (median 7 months; median SpO Respiratory support with HFNT showing potential benefit should prompt further trials.

Identifiants

DOI: 10.1007/s00134-021-06385-3 PMID: 33954839 PMC: PMC8098782

pubmed: 33954839

doi: 10.1007/s00134-021-06385-3

pii: 10.1007/s00134-021-06385-3

pmc: PMC8098782

doi:

Substances chimiques

Oxygen S88TT14065

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

Pagination

566-576

Subventions

Organisme : Wellcome Trust

ID : 202800/Z/16/Z

Pays : United Kingdom

Organisme : European & Developing Countries Clinical Trials Partnership

ID : EDCTP_RIA2016S-1636

Pays : Netherlands

Organisme : Medical Research Council

ID : MR/L004364/1

Pays : United Kingdom

Investigateurs

A Turnbull (A)

A Odit (A)

E Molyneux (E)

I Lubega (I)

W Macharia (W)

J Crawley (J)

M Peters (M)

T Peto (T)

P Musoke (P)

F Were (F)

C Semple (C)

J Todd (J)

Commentaires et corrections

Type : CommentIn

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