Dorsal periaqueductal gray ensembles represent approach and avoidance states.
behavioral states
calcium imaging
elevated plus maze
fear
mouse
neuroscience
periaqueductal gray
predator
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
06 05 2021
06 05 2021
Historique:
received:
16
11
2020
accepted:
05
05
2021
pubmed:
7
5
2021
medline:
14
12
2021
entrez:
6
5
2021
Statut:
epublish
Résumé
Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from threats such as the open arms of the elevated plus maze and a predator. These cells were also more active during threat avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat approach ensemble was more active during risk assessment behaviors and near threats. Furthermore, unsupervised methods showed that avoidance/approach states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flexible mechanism to balance risk assessment and danger avoidance.
Identifiants
pubmed: 33955356
doi: 10.7554/eLife.64934
pii: 64934
pmc: PMC8133778
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : F31 MH121050
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH106649
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH106649
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119089
Pays : United States
Informations de copyright
© 2021, Reis et al.
Déclaration de conflit d'intérêts
FR, JL, SM, PS, MC, JL, ML, BT, JI, AK, NC, JK, AA No competing interests declared
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