How Protein Methylation Regulates Steroid Receptor Function.
AR
ERα
GR
PR
coregulators
lysine methyltransferases
methylation
protein arginine methyltransferases
protein demethylases
steroid receptors
Journal
Endocrine reviews
ISSN: 1945-7189
Titre abrégé: Endocr Rev
Pays: United States
ID NLM: 8006258
Informations de publication
Date de publication:
12 01 2022
12 01 2022
Historique:
received:
16
02
2021
pubmed:
7
5
2021
medline:
26
4
2022
entrez:
6
5
2021
Statut:
ppublish
Résumé
Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance of vital biological pathways, including development, reproduction, and metabolic homeostasis. In addition, aberrant expression of SRs or dysregulation of their signaling has been observed in a wide variety of pathologies. SR activity is tightly and finely controlled by post-translational modifications (PTMs) targeting the receptors and/or their coregulators. Whereas major attention has been focused on phosphorylation, growing evidence shows that methylation is also an important regulator of SRs. Interestingly, the protein methyltransferases depositing methyl marks are involved in many functions, from development to adult life. They have also been associated with pathologies such as inflammation, as well as cardiovascular and neuronal disorders, and cancer. This article provides an overview of SR methylation/demethylation events, along with their functional effects and biological consequences. An in-depth understanding of the landscape of these methylation events could provide new information on SR regulation in physiology, as well as promising perspectives for the development of new therapeutic strategies, illustrated by the specific inhibitors of protein methyltransferases that are currently available.
Identifiants
pubmed: 33955470
pii: 6270645
doi: 10.1210/endrev/bnab014
pmc: PMC8755998
doi:
Substances chimiques
Receptors, Steroid
0
Protein Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
160-197Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK043093
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
Références
Exp Mol Med. 2017 Apr 28;49(4):e324
pubmed: 28450737
Mol Biol Cell. 2016 Apr 15;27(8):1358-66
pubmed: 26912789
Cell Death Differ. 2012 May;19(5):859-70
pubmed: 22095282
Mol Cell Biol. 2004 Dec;24(24):10542-57
pubmed: 15572662
Cell Rep. 2020 Sep 29;32(13):108172
pubmed: 32997990
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6868-6877
pubmed: 30886105
AIDS. 2007 Apr 23;21(7):795-805
pubmed: 17415034
Cell. 1988 Jul 29;54(3):313-23
pubmed: 3396073
J Mol Endocrinol. 2020 Jul;65(1):T1-T14
pubmed: 31809260
EMBO J. 2010 Jun 2;29(11):1803-16
pubmed: 20389281
Oncol Lett. 2021 Feb;21(2):93
pubmed: 33376526
Clin Epigenetics. 2019 Aug 1;11(1):112
pubmed: 31370883
EMBO Mol Med. 2012 Nov;4(11):1200-13
pubmed: 23065768
Neoplasia. 2012 Jun;14(6):476-86
pubmed: 22787429
Elife. 2016 May 16;5:
pubmed: 27183006
Curr Top Med Chem. 2011;11(13):1668-83
pubmed: 21463254
Structure. 2011 Sep 7;19(9):1262-73
pubmed: 21782458
EMBO J. 2010 Mar 17;29(6):1105-15
pubmed: 20111005
J Biol Chem. 2010 Mar 26;285(13):9636-9641
pubmed: 20118233
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):224-9
pubmed: 16373508
Mol Cell. 2006 Oct 20;24(2):233-43
pubmed: 17052457
Mol Cell. 2017 Mar 2;65(5):900-916.e7
pubmed: 28238654
EMBO J. 2013 May 29;32(11):1556-67
pubmed: 23624934
Biochem Biophys Res Commun. 2020 May 14;525(4):1018-1024
pubmed: 32178870
Science. 1995 Dec 1;270(5241):1491-4
pubmed: 7491495
Mol Cell. 2010 Jul 9;39(1):71-85
pubmed: 20603076
J Neurosci. 2017 Nov 8;37(45):10998-11020
pubmed: 28986464
EMBO J. 2007 Apr 4;26(7):1831-42
pubmed: 17347654
Int J Biol Sci. 2020 Jun 27;16(13):2382-2391
pubmed: 32760206
Blood. 2020 Oct 22;136(17):1919-1932
pubmed: 32573733
Mol Cell. 2007 Sep 7;27(5):691-700
pubmed: 17803935
Free Radic Biol Med. 2020 Oct;158:60-73
pubmed: 32679368
Steroids. 2010 Jan;75(1):1-12
pubmed: 19818358
Science. 1971 Feb 12;171(3971):579-81
pubmed: 4924231
Int J Mol Sci. 2019 Jun 05;20(11):
pubmed: 31195751
Biochim Biophys Acta. 2013 Apr;1833(4):812-22
pubmed: 23047121
Science. 1986 Aug 15;233(4765):767-70
pubmed: 2426779
Mol Cell. 2007 Aug 17;27(4):596-608
pubmed: 17707231
Aging (Albany NY). 2012 Jul;4(7):462-79
pubmed: 22820736
Cell. 2009 Jul 23;138(2):245-56
pubmed: 19632176
Nature. 2006 Feb 16;439(7078):811-6
pubmed: 16362057
Genes Dev. 2016 Apr 1;30(7):772-85
pubmed: 26988419
Cancer Res. 2000 Aug 1;60(15):4026-9
pubmed: 10945602
iScience. 2020 Jun 26;23(6):101236
pubmed: 32563156
World J Biol Chem. 2014 May 26;5(2):115-29
pubmed: 24921003
PLoS One. 2010 Jun 29;5(6):e11379
pubmed: 20614009
J Biol Chem. 2010 Apr 23;285(17):12695-705
pubmed: 20159986
Mol Cell. 2017 Aug 17;67(4):550-565.e5
pubmed: 28803780
Diabetes. 2009 Jan;58(1):185-93
pubmed: 18984737
Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3:298-305
pubmed: 26184856
Cancer Res. 2020 Oct 15;80(20):4500-4513
pubmed: 32699135
Mol Cell Endocrinol. 2011 Mar 30;335(2):148-57
pubmed: 21238538
Genes Dev. 2002 Jul 15;16(14):1779-91
pubmed: 12130538
EMBO J. 2012 Apr 4;31(7):1785-97
pubmed: 22327218
Science. 2009 Jul 3;325(5936):90-3
pubmed: 19574390
Proc Natl Acad Sci U S A. 1971 Apr;68(4):765-9
pubmed: 4994464
Cancer Cell. 2011 Oct 18;20(4):457-71
pubmed: 22014572
Nucleic Acids Res. 2012 Oct;40(19):9513-21
pubmed: 22904064
EMBO J. 2009 Apr 22;28(8):1055-66
pubmed: 19262565
J Biol Chem. 2014 Aug 29;289(35):24325-35
pubmed: 25012667
Biochem Soc Trans. 2000;28(4):415-8
pubmed: 10961931
Neoplasia. 2015 Apr;17(4):367-73
pubmed: 25925379
Science. 1999 Jun 25;284(5423):2174-7
pubmed: 10381882
EMBO Rep. 2000 Aug;1(2):151-7
pubmed: 11265755
Cell Rep. 2020 Dec 15;33(11):108504
pubmed: 33326791
Nature. 2007 Apr 19;446(7138):882-7
pubmed: 17392792
Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118611
pubmed: 31751593
Trends Biochem Sci. 2020 Jun;45(6):497-510
pubmed: 32413325
Mol Endocrinol. 2005 Apr;19(4):833-42
pubmed: 15695368
J Biol Chem. 2013 Dec 6;288(49):35093-103
pubmed: 24129573
Science. 2007 Oct 19;318(5849):444-7
pubmed: 17947579
Nat Rev Mol Cell Biol. 2019 Oct;20(10):642-657
pubmed: 31350521
Mol Endocrinol. 1997 Jul;11(8):1114-28
pubmed: 9212059
Biochim Biophys Acta. 2016 Aug;1863(8):2093-103
pubmed: 27183873
Nucleic Acids Res. 2014 Sep;42(15):9908-24
pubmed: 25104022
Prog Nucleic Acid Res Mol Biol. 1998;61:65-131
pubmed: 9752719
Nat Rev Drug Discov. 2004 Nov;3(11):950-64
pubmed: 15520817
Oncotarget. 2016 Sep 27;7(39):63629-63639
pubmed: 27571165
Cell Stem Cell. 2014 Dec 4;15(6):735-49
pubmed: 25479749
Oncotarget. 2014 Mar 30;5(6):1434-8
pubmed: 24727738
Nucleic Acids Res. 2017 Nov 2;45(19):11106-11120
pubmed: 28977470
Cell Death Differ. 2020 Dec;27(12):3226-3242
pubmed: 32895488
J Biol Chem. 2018 Oct 19;293(42):16479-16487
pubmed: 30190324
Cell Death Differ. 2021 Apr;28(4):1251-1269
pubmed: 33116296
Cell. 2006 May 5;125(3):467-81
pubmed: 16603238
Trends Biochem Sci. 2004 Jun;29(6):317-24
pubmed: 15276186
Blood. 2018 Nov 8;132(19):2026-2039
pubmed: 30082494
Autophagy. 2019 Jun;15(6):1069-1081
pubmed: 30653406
Cell Rep. 2013 Dec 26;5(6):1625-38
pubmed: 24332853
Biochem J. 2017 Aug 11;474(17):2951
pubmed: 28801480
Nucleic Acids Res. 2019 Jan 10;47(1):184-196
pubmed: 30357346
Steroids. 2018 May;133:2-7
pubmed: 29155216
Endocrinology. 2021 Feb 1;162(2):
pubmed: 33284960
Nat Commun. 2015 Sep 30;6:8419
pubmed: 26420673
J Biol Chem. 2010 Nov 26;285(48):37733-40
pubmed: 20870719
Nat Commun. 2011 Nov 15;2:533
pubmed: 22086334
Mol Cell. 2006 Apr 7;22(1):51-62
pubmed: 16600869
Mol Cell. 2004 Apr 23;14(2):175-82
pubmed: 15099517
Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591
pubmed: 29860315
Nature. 2007 Sep 6;449(7158):105-8
pubmed: 17805299
Front Immunol. 2019 Jul 04;10:1545
pubmed: 31333672
Cancers (Basel). 2019 Nov 20;11(12):
pubmed: 31756917
Front Oncol. 2019 Apr 26;9:306
pubmed: 31106145
Biochemistry. 2016 Mar 22;55(11):1557-69
pubmed: 26652298
Biomed Pharmacother. 2006 Nov;60(9):520-8
pubmed: 16949786
Open Biol. 2013 Oct 02;3(10):120173
pubmed: 24088713
Biochemistry. 2001 May 15;40(19):5747-56
pubmed: 11341840
Mol Cell Biol. 2012 Apr;32(7):1202-13
pubmed: 22269951
Biomolecules. 2018 Feb 27;8(1):
pubmed: 29495487
Mol Endocrinol. 1996 Oct;10(10):1167-77
pubmed: 9121485
Cell. 2004 Dec 29;119(7):941-53
pubmed: 15620353
Nat Struct Biol. 1996 Feb;3(2):206
pubmed: 8564548
Science. 1990 Dec 21;250(4988):1740-3
pubmed: 2176746
Mol Cell Biol. 2006 Mar;26(6):2273-85
pubmed: 16508003
Genes Dev. 2008 Mar 1;22(5):640-53
pubmed: 18316480
Cell. 1995 Dec 15;83(6):835-9
pubmed: 8521507
Nat Commun. 2016 Mar 10;7:10810
pubmed: 26960573
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5317-E5325
pubmed: 29773710
Sci Rep. 2019 Jan 15;9(1):119
pubmed: 30644418
J Biol Chem. 1993 May 15;268(14):10501-9
pubmed: 7683681
Biochem J. 2016 Jul 15;473(14):1995-2009
pubmed: 27407169
J Biol Chem. 2020 Dec 11;295(50):17060-17070
pubmed: 33008887
Cell Prolif. 2020 Feb;53(2):e12747
pubmed: 31961032
Cancer Res. 2007 May 1;67(9):4514-23
pubmed: 17483368
R I Med J (2013). 2020 Jun 19;103(6):39-43
pubmed: 32570995
Nature. 2013 Aug 29;500(7464):598-602
pubmed: 23945587
Int J Mol Sci. 2020 Feb 27;21(5):
pubmed: 32120841
Cell Rep. 2019 Nov 5;29(6):1482-1498.e4
pubmed: 31693890
Mol Cell Endocrinol. 2007 Feb;265-266:162-7
pubmed: 17240047
Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20706-20716
pubmed: 32764145
Mol Cell Endocrinol. 2010 Oct 7;327(1-2):19-24
pubmed: 20603181
Genes Dev. 2005 Mar 15;19(6):671-6
pubmed: 15741314
Endocr Rev. 2011 Oct;32(5):597-622
pubmed: 21680538
Cell. 2002 Feb 22;108(4):465-74
pubmed: 11909518
Nat Immunol. 2017 Aug;18(8):911-920
pubmed: 28628091
Curr Opin Nephrol Hypertens. 2014 Jan;23(1):32-7
pubmed: 24275769
Nucleic Acids Res. 2018 Jun 20;46(11):5601-5617
pubmed: 29718323
Nature. 2007 Oct 18;449(7164):933-7
pubmed: 17898714
Mol Endocrinol. 2011 Sep;25(9):1527-38
pubmed: 21835891
Nat Commun. 2016 Jun 23;7:11974
pubmed: 27337104
J Biol Chem. 2018 Aug 17;293(33):12770-12780
pubmed: 29959229
J Biol Chem. 2000 Jul 7;275(27):20853-60
pubmed: 10779504
Trends Genet. 2001 Oct;17(10):554-6
pubmed: 11585645
Commun Biol. 2020 Aug 5;3(1):428
pubmed: 32759981
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6803-8
pubmed: 9192646
Genome Biol. 2005;6(8):227
pubmed: 16086857
Mol Cell. 2017 Jan 5;65(1):8-24
pubmed: 28061334
Cancer Lett. 2014 Aug 28;351(1):126-33
pubmed: 24880080
Nature. 1986 Mar 13-19;320(6058):134-9
pubmed: 3754034
ACS Med Chem Lett. 2015 Apr 06;6(6):655-9
pubmed: 26101569
Cell. 1990 Mar 23;60(6):953-62
pubmed: 2317866
J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):323-34
pubmed: 10935020
Int J Dev Biol. 2013;57(5):357-64
pubmed: 23873367
Mol Cell Biol. 2011 Apr;31(7):1540-50
pubmed: 21262773
Science. 2003 Sep 19;301(5640):1714-7
pubmed: 14500980
Mol Cell. 2016 Nov 17;64(4):673-687
pubmed: 27840030
Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194442
pubmed: 31634638
Mol Cell. 2009 Jan 16;33(1):1-13
pubmed: 19150423
Future Med Chem. 2019 May;11(9):993-1014
pubmed: 31141392
Expert Rev Proteomics. 2017 Feb;14(2):157-170
pubmed: 28043171
J Biol Chem. 2009 Jun 26;284(26):17775-82
pubmed: 19407342
J Biol Chem. 2002 Jul 19;277(29):25904-13
pubmed: 11994312
Cancer Res. 2016 Mar 1;76(5):1260-72
pubmed: 26759235
Mol Immunol. 2013 Dec;56(4):390-8
pubmed: 23911394
Exp Cell Res. 2009 Apr 15;315(7):1273-86
pubmed: 19124016
Oncogene. 2010 Apr 22;29(16):2357-67
pubmed: 20140018
J Biol Chem. 2015 Jul 31;290(31):19044-54
pubmed: 26070566
Biochimie. 2016 May;124:92-97
pubmed: 26133657
J Biol Chem. 1992 May 25;267(15):10882-7
pubmed: 1587864
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13516-21
pubmed: 23904475
Mol Endocrinol. 2005 Jun;19(6):1418-28
pubmed: 15914711
Genes Dev. 2013 May 15;27(10):1179-97
pubmed: 23699411
Nat Commun. 2020 Dec 8;11(1):6297
pubmed: 33293536
Cancer Cell. 2019 Jul 8;36(1):100-114.e25
pubmed: 31257072
Int J Mol Sci. 2015 Dec 10;16(12):29467-81
pubmed: 26690413
Commun Biol. 2019 Jan 18;2:23
pubmed: 30675521
Science. 2008 Jan 11;319(5860):202-6
pubmed: 18187655
J Biol Chem. 2014 May 30;289(22):15328-39
pubmed: 24753255
Cell Rep. 2018 Oct 16;25(3):690-701.e8
pubmed: 30332648
EMBO J. 2011 Oct 14;30(23):4764-76
pubmed: 22002538
Nat Commun. 2018 Nov 30;9(1):5107
pubmed: 30504773
Pharmacol Ther. 2007 Jan;113(1):50-87
pubmed: 17005254
Cell Stem Cell. 2012 Sep 7;11(3):333-45
pubmed: 22863532
Nucleic Acids Res. 2019 Feb 28;47(4):1692-1705
pubmed: 30535125
Nature. 1995 Dec 14;378(6558):681-9
pubmed: 7501014
Nucleic Acids Res. 2001 Sep 15;29(18):3784-95
pubmed: 11557810
Nature. 1999 Nov 4;402(6757):93-6
pubmed: 10573424
J Biol Chem. 1996 Jun 21;271(25):15034-44
pubmed: 8663146
Nat Commun. 2020 Aug 19;11(1):4153
pubmed: 32814769
Nature. 2006 Nov 30;444(7119):629-32
pubmed: 17108971
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6085-90
pubmed: 21444773
Nature. 2005 Sep 15;437(7057):436-9
pubmed: 16079795
Cancer Res. 2020 Nov 15;80(22):4904-4917
pubmed: 32999000
Prostate. 2006 Sep 1;66(12):1292-301
pubmed: 16705743
N Engl J Med. 2019 Jul 4;381(1):13-24
pubmed: 31150574
Mol Cell. 2003 Mar;11(3):695-707
pubmed: 12667452
Mol Cell. 2005 Sep 16;19(6):857-64
pubmed: 16140033
Nat Rev Rheumatol. 2012 Nov;8(11):645-55
pubmed: 23045254
Curr Opin Struct Biol. 2006 Dec;16(6):753-60
pubmed: 17070031
J Biol Chem. 2015 May 22;290(21):13479-89
pubmed: 25847239
PLoS One. 2014 Feb 03;9(2):e87982
pubmed: 24498420
Virology. 2014 Mar;452-453:1-11
pubmed: 24606677
Neoplasia. 2014 Mar;16(3):257-64, 264.e2
pubmed: 24726141
N Engl J Med. 2005 Oct 20;353(16):1711-23
pubmed: 16236742
PLoS One. 2016 Feb 22;11(2):e0148905
pubmed: 26901772
Genes Dev. 1993 Jul;7(7B):1400-10
pubmed: 8392477
Cancer Res. 2011 Aug 15;71(16):5579-87
pubmed: 21700716
EMBO J. 2008 Oct 22;27(20):2681-90
pubmed: 18818694
Nat Med. 2019 Jul;25(7):1073-1081
pubmed: 31270502
Oncotarget. 2017 Jul 27;8(34):55837-55847
pubmed: 28915556
Cell. 1989 Feb 10;56(3):335-44
pubmed: 2644044
Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G937-47
pubmed: 22345554
Mol Cell. 2008 May 9;30(3):336-47
pubmed: 18471979
Nucleic Acids Res. 2014 Jan;42(1):224-34
pubmed: 24078251
Curr Pharm Biotechnol. 2004 Oct;5(5):459-70
pubmed: 15544494
Mol Endocrinol. 1992 Mar;6(3):429-42
pubmed: 1316541
PLoS One. 2020 May 29;15(5):e0233468
pubmed: 32469975
Genes Dev. 2011 Jan 15;25(2):176-88
pubmed: 21245169
Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1032-7
pubmed: 10655479
Cancer Res. 2009 Apr 15;69(8):3339-46
pubmed: 19318566
Mol Cell Biol. 2000 Mar;20(5):1855-67
pubmed: 10669760
Biochim Biophys Acta Gene Regul Mech. 2019 Apr;1862(4):522-533
pubmed: 30716532
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):841-6
pubmed: 22215600
Oncogene. 2011 May 19;30(20):2379-89
pubmed: 21242974
Retrovirology. 2006 Dec 18;3:93
pubmed: 17176473
Atherosclerosis. 2020 Sep;308:22-31
pubmed: 32799103
Front Endocrinol (Lausanne). 2018 Aug 28;9:492
pubmed: 30210453
J Biol Chem. 2013 Mar 1;288(9):6053-62
pubmed: 23303181
Autophagy. 2018;14(5):825-844
pubmed: 29634390
EMBO Rep. 2002 Jan;3(1):39-44
pubmed: 11751582
Neuron. 2015 Jan 7;85(1):88-100
pubmed: 25569348
PLoS One. 2011;6(10):e27026
pubmed: 22046437
Oncotarget. 2016 Oct 11;7(41):67532-67550
pubmed: 27556302
Int J Mol Sci. 2020 May 17;21(10):
pubmed: 32429593
Cancer Res. 2017 Sep 1;77(17):4613-4625
pubmed: 28655788
Nature. 2004 Nov 18;432(7015):353-60
pubmed: 15525938
Biochem J. 2005 Nov 1;391(Pt 3):449-64
pubmed: 16238547
J Hematol Oncol. 2019 Dec 4;12(1):129
pubmed: 31801559
Cancer Res. 2004 Dec 15;64(24):9199-208
pubmed: 15604293
Sci Adv. 2019 Nov 06;5(11):eaaw8145
pubmed: 31723599
Int J Cardiol. 2019 May 1;282:76-80
pubmed: 30772011
J Biol Chem. 2004 Jun 4;279(23):23892-9
pubmed: 15056663
Nature. 1991 Aug 8;352(6335):497-505
pubmed: 1865905
J Cancer. 2017 Jul 5;8(11):2069-2078
pubmed: 28819408
Trends Cell Biol. 2021 May;31(5):402-417
pubmed: 33485722
Science. 2011 Apr 1;332(6025):99-103
pubmed: 21454787
Cell Res. 2010 Sep;20(9):1023-33
pubmed: 20421892
Endocr Rev. 2005 Apr;26(2):147-70
pubmed: 15479858
Int Rev Cell Mol Biol. 2015;319:165-220
pubmed: 26404469
Mol Med Rep. 2019 May;19(5):3963-3971
pubmed: 30942418
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1925-30
pubmed: 21245319
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3327-36
pubmed: 26080448
J Biol Chem. 2014 Feb 28;289(9):5704-22
pubmed: 24415758
Oncotarget. 2015 Nov 3;6(34):35173-82
pubmed: 26460953
J Biol Chem. 2001 Jan 12;276(2):1089-98
pubmed: 11050077
Biochem Biophys Res Commun. 2009 Jul 24;385(2):273-8
pubmed: 19460357
Cancer Cell. 2015 Jul 13;28(1):57-69
pubmed: 26175415
PLoS Genet. 2008 Sep 12;4(9):e1000190
pubmed: 18787701
Nucleic Acids Res. 2011 Apr;39(7):2717-26
pubmed: 21138967
FEBS J. 2017 Sep;284(17):2732-2744
pubmed: 28294537
Cell Cycle. 2012 Dec 15;11(24):4597-612
pubmed: 23187807
Cell Mol Life Sci. 2019 Aug;76(15):2873-2883
pubmed: 31123776
Cell. 2003 Dec 12;115(6):751-63
pubmed: 14675539
J Cell Sci. 2007 Dec 15;120(Pt 24):4243-6
pubmed: 18057026
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19673-8
pubmed: 23151507
Mol Cell. 2018 Apr 19;70(2):340-357.e8
pubmed: 29628309
Mol Cell. 2008 Jul 25;31(2):212-21
pubmed: 18657504
Physiol Behav. 2010 Feb 9;99(2):151-62
pubmed: 19737574
Mol Cell Biol. 2009 Feb;29(3):745-57
pubmed: 19047371
Int J Biochem Cell Biol. 2012 Dec;44(12):2333-41
pubmed: 23032699
Mol Cell Biol. 2006 Nov;26(21):7846-57
pubmed: 16923966
Diabetes. 2005 Apr;54(4):1000-8
pubmed: 15793238
Biomed Pharmacother. 2019 Jun;114:108790
pubmed: 30903920
Oncotarget. 2018 Apr 6;9(26):18480-18493
pubmed: 29719619
Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118615
pubmed: 31765670
Nucleic Acids Res. 2018 Apr 6;46(6):3061-3074
pubmed: 29471495
Endocr Rev. 2020 Oct 1;41(5):
pubmed: 32365199
Cell. 2001 Mar 9;104(5):731-41
pubmed: 11257227
FASEB J. 2020 Mar;34(3):3461-3484
pubmed: 31961018
Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000
pubmed: 31439820
Mol Cell. 2013 Feb 21;49(4):704-18
pubmed: 23352453
Cell Rep. 2014 Dec 11;9(5):1618-1627
pubmed: 25482560
EMBO Rep. 2020 Feb 5;21(2):e48597
pubmed: 31833203
Mol Cell. 2013 Jul 11;51(1):5-19
pubmed: 23747011
Mol Endocrinol. 2005 Nov;19(11):2671-84
pubmed: 15961505
EMBO J. 2002 Oct 15;21(20):5457-66
pubmed: 12374746
Nucleic Acids Res. 2011 Jun;39(11):4719-27
pubmed: 21321020
Mol Cell Proteomics. 2011 Jan;10(1):M110.000976
pubmed: 20930037
Cell. 2007 Feb 9;128(3):505-518
pubmed: 17289570
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5076-81
pubmed: 19282482
Mol Cell Biol. 2007 Jan;27(1):120-34
pubmed: 17043108
PLoS One. 2015 May 07;10(5):e0126181
pubmed: 25951181
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4326-31
pubmed: 27051065
Sci Rep. 2020 Sep 28;10(1):15934
pubmed: 32985589
Elife. 2018 Jan 31;7:
pubmed: 29384474
Curr Biol. 2001 Jun 26;11(12):996-1000
pubmed: 11448779
Nat Cell Biol. 2007 Mar;9(3):347-53
pubmed: 17277772
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18972-7
pubmed: 19864627
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6464-8
pubmed: 12756295
J Biol Chem. 2015 Aug 14;290(33):20556-64
pubmed: 26149688
Nat Genet. 2020 Oct;52(10):1011-1017
pubmed: 32868907
J Biol Chem. 1970 Jan 10;245(1):88-92
pubmed: 5411548
J Biol Chem. 2018 Nov 9;293(45):17454-17463
pubmed: 30257864
J Steroid Biochem Mol Biol. 2007 Oct;107(1-2):1-14
pubmed: 17587566
Methods. 2020 Mar 15;175:66-71
pubmed: 31499160
Science. 2001 Aug 3;293(5531):853-7
pubmed: 11387442
Nat Commun. 2016 Jan 13;7:10347
pubmed: 26757928
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3611-6
pubmed: 15731352
Sci Rep. 2015 May 28;5:10475
pubmed: 26020839
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3052-3061
pubmed: 30733284
Nucleic Acids Res. 2007;35(21):7313-23
pubmed: 17962312
Cell Host Microbe. 2010 Mar 18;7(3):234-44
pubmed: 20227666
Pharmacol Ther. 2013 Dec;140(3):223-38
pubmed: 23859952
Oncogene. 2019 May;38(21):4015-4027
pubmed: 30692633
Nat Chem Biol. 2008 Jun;4(6):344-6
pubmed: 18438403
Nat Cell Biol. 2008 Dec;10(12):1431-9
pubmed: 19011621
FEBS Lett. 2014 May 2;588(9):1542-8
pubmed: 24726729
Sci Rep. 2016 Feb 23;6:21718
pubmed: 26902152
Cell Rep. 2018 Apr 10;23(2):389-403
pubmed: 29641999
Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2143-2158
pubmed: 32640903
Curr Protein Pept Sci. 2020;21(7):655-674
pubmed: 31894745
Mol Cell. 2010 Dec 10;40(5):736-48
pubmed: 21145482
Sci Rep. 2020 Dec 3;10(1):21160
pubmed: 33273660
Mol Endocrinol. 2011 Mar;25(3):433-44
pubmed: 21273441
Cell Rep. 2016 Jan 26;14(3):479-492
pubmed: 26774474
Science. 1988 Dec 9;242(4884):1418-20
pubmed: 3201230
FASEB J. 2018 Jun 19;:fj201800244RR
pubmed: 29920217
J Biol Chem. 2008 Sep 26;283(39):26771-81
pubmed: 18650421
Essays Biochem. 2004;40:11-26
pubmed: 15242336
Mol Cancer. 2018 Oct 22;17(1):153
pubmed: 30348169
Oncotarget. 2015 Jul 10;6(19):17221-36
pubmed: 25980497
Biochem Biophys Res Commun. 2011 Jan 28;404(4):991-6
pubmed: 21187067
J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):236-41
pubmed: 18434134
Mol Cell Endocrinol. 2012 Jun 24;357(1-2):43-9
pubmed: 21945472
Biomed Pharmacother. 2020 Sep;129:110392
pubmed: 32574968
Elife. 2015 Nov 17;4:
pubmed: 26575292
J Biol Chem. 2002 Aug 9;277(32):28624-30
pubmed: 12039952
Curr Opin Cell Biol. 1998 Jun;10(3):384-91
pubmed: 9640540
Nat Struct Mol Biol. 2007 Nov;14(11):1025-1040
pubmed: 17984965
Dev Biol. 1974 Jul;39(1):141-57
pubmed: 4209831
Nat Chem Biol. 2010 Oct;6(10):766-73
pubmed: 20729856
Nature. 1959 Jul 4;184:56-7
pubmed: 13793118
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5516-21
pubmed: 23509280
Biochem Biophys Res Commun. 2019 May 28;513(2):340-346
pubmed: 30955858
J Proteome Res. 2008 Oct;7(10):4538-45
pubmed: 18781795
ChemMedChem. 2018 Aug 10;13(15):1530-1540
pubmed: 29882380
Mol Cell. 2014 Aug 21;55(4):537-51
pubmed: 25042802
Cancer Res. 2011 Feb 1;71(3):655-60
pubmed: 21115810
Nature. 2016 Jan 7;529(7584):48-53
pubmed: 26700805
Sci Adv. 2015 Oct 09;1(9):e1500463
pubmed: 26601288
Curr Protoc Protein Sci. 2016 Nov 1;86:24.8.1-24.8.19
pubmed: 27801517
Aging (Albany NY). 2019 Dec 4;11(23):11591-11608
pubmed: 31804189
Cancer Sci. 2016 Apr;107(4):377-84
pubmed: 26751963
J Dent Res. 2018 Jul;97(7):810-819
pubmed: 29420098
EMBO Rep. 2018 Dec;19(12):
pubmed: 30420520
Nat Med. 2021 Feb;27(2):310-320
pubmed: 33462444
Int J Mol Sci. 2020 Aug 24;21(17):
pubmed: 32847068
J Biol Chem. 2002 Nov 22;277(47):44623-30
pubmed: 12237300
Cancer Res. 2019 Jun 1;79(11):2865-2877
pubmed: 31015230
Sci Signal. 2011 Sep 13;4(190):ra58
pubmed: 21917714
J Mol Endocrinol. 2017 Jan;58(1):R15-R31
pubmed: 27729460
Mol Cell. 2010 Jul 9;39(1):152-60
pubmed: 20603083
Cancer Cell Int. 2018 May 9;18:71
pubmed: 29760584
Nucleic Acids Res. 2005 Jan 07;33(1):13-26
pubmed: 15640443
Nature. 2010 Apr 1;464(7289):792-6
pubmed: 20228790
Adv Exp Med Biol. 2015;872:315-33
pubmed: 26216001
Adv Sci (Weinh). 2020 Oct 16;7(23):2002602
pubmed: 33304767
Sci China Life Sci. 2020 Sep;63(9):1394-1405
pubmed: 32157557
FASEB J. 2007 Jan;21(1):26-34
pubmed: 17116746
EMBO J. 2006 Nov 1;25(21):5094-104
pubmed: 17053781
Epigenetics Chromatin. 2018 Oct 4;11(1):56
pubmed: 30286792
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17284-9
pubmed: 24101509
Chembiochem. 2020 Jan 15;21(1-2):256-264
pubmed: 31612581
BMC Cancer. 2014 Apr 22;14:275
pubmed: 24755251
J Cell Sci. 2003 Feb 15;116(Pt 4):585-6
pubmed: 12538758
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16701-6
pubmed: 12481024
Curr Opin Chem Biol. 2017 Aug;39:100-108
pubmed: 28662389
Cancers (Basel). 2019 Mar 07;11(3):
pubmed: 30866496
Science. 2000 Sep 8;289(5485):1751-4
pubmed: 10976068
Mol Cell. 2008 Feb 15;29(3):392-400
pubmed: 18280244
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21499-504
pubmed: 21098664
Biochim Biophys Acta. 2014 Sep;1843(9):2067-78
pubmed: 24742914
Dev Cell. 2013 Jul 29;26(2):188-94
pubmed: 23850191
Mol Cell. 2013 Oct 10;52(1):37-51
pubmed: 24076217
J Biol Chem. 2008 Sep 26;283(39):26357-63
pubmed: 18647749
Cell Death Dis. 2018 Oct 10;9(10):1038
pubmed: 30305606
Cell Discov. 2017 Oct 03;3:17035
pubmed: 29098080
Cell Rep. 2018 Sep 18;24(12):3207-3223
pubmed: 30232003
Science. 2004 Oct 8;306(5694):279-83
pubmed: 15345777
Elife. 2020 Oct 27;9:
pubmed: 33107819
Retrovirology. 2013 Jul 17;10:73
pubmed: 23866860
Nat Rev Cancer. 2013 Jan;13(1):37-50
pubmed: 23235912
Elife. 2016 Jul 28;5:
pubmed: 27466704
Mol Cell. 2021 Mar 18;81(6):1276-1291.e9
pubmed: 33539787
Mol Cancer. 2006 Jun 28;5:26
pubmed: 16805913
Cells. 2019 Feb 19;8(2):
pubmed: 30791431
Signal Transduct Target Ther. 2019 Jul 26;4:24
pubmed: 31637004
FASEB J. 2015 Oct;29(10):4313-23
pubmed: 26116705
Oncotarget. 2016 Aug 16;7(33):53018-53028
pubmed: 27323813
J Biol Chem. 2018 Sep 28;293(39):15290-15303
pubmed: 30131339
Trends Pharmacol Sci. 2000 Oct;21(10):381-8
pubmed: 11050318
Endocr Relat Cancer. 2013 Dec 16;21(1):51-61
pubmed: 24200674
J Biol Chem. 2017 Nov 17;292(46):18886-18896
pubmed: 28972166
J Biol Chem. 2016 Oct 21;291(43):22671-22685
pubmed: 27601476
Signal Transduct Target Ther. 2020 Sep 30;5(1):197
pubmed: 32994405
Biochemistry. 1964 Jan;3:10-5
pubmed: 14114491
J Biol Chem. 1970 Nov 10;245(21):5751-8
pubmed: 5472370
Nucleic Acids Res. 2017 May 5;45(8):4359-4369
pubmed: 28115626
Genes Dev. 2005 Apr 1;19(7):815-26
pubmed: 15774718
Am J Physiol Endocrinol Metab. 2021 Jan 1;320(1):E160-E168
pubmed: 33225718
Histol Histopathol. 2016 Mar;31(3):329-37
pubmed: 26544916
Future Med Chem. 2019 Apr;11(8):901-921
pubmed: 30998113
Autoimmun Rev. 2012 May;11(6-7):A502-14
pubmed: 22193289
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13510-5
pubmed: 21825155
Genes Dev. 2005 Jun 15;19(12):1466-73
pubmed: 15964996
J Autoimmun. 2019 Feb;97:10-21
pubmed: 30318155
Curr Biol. 2002 Dec 23;12(24):2090-7
pubmed: 12498683
Nat Commun. 2016 Feb 12;7:10574
pubmed: 26868148
Genes Dev. 2011 Jun 1;25(11):1132-46
pubmed: 21632823
Mol Endocrinol. 2012 May;26(5):762-74
pubmed: 22446104
Cancer Cell. 2014 Jan 13;25(1):21-36
pubmed: 24434208
J Virol. 2007 Apr;81(8):4226-34
pubmed: 17267505
Curr Biol. 2001 Dec 11;11(24):1981-5
pubmed: 11747826
J Steroid Biochem Mol Biol. 2014 Mar;140:80-9
pubmed: 24333793
Cell Rep. 2016 Jun 21;15(12):2733-44
pubmed: 27292644
J Biol Chem. 2017 Aug 11;292(32):13333-13344
pubmed: 28652407
Mol Cell. 2008 Oct 24;32(2):221-31
pubmed: 18951090
Front Endocrinol (Lausanne). 2019 Aug 20;10:569
pubmed: 31481932
J Biol Chem. 2018 Aug 24;293(34):13059-13072
pubmed: 29907569
Cancer Res. 2004 Nov 15;64(22):8365-73
pubmed: 15548706
J Biol Chem. 2015 Sep 4;290(36):22236-49
pubmed: 26221041
Endocr Rev. 1998 Feb;19(1):3-17
pubmed: 9494778
J Med Chem. 2016 Apr 28;59(8):3650-60
pubmed: 27088648
J Biol Chem. 2016 Jul 29;291(31):16240-8
pubmed: 27235396
Nucleic Acids Res. 2011 Mar;39(4):1266-79
pubmed: 20959290
J Mol Cell Biol. 2011 Oct;3(5):301-8
pubmed: 22028380
Front Immunol. 2015 Sep 25;6:487
pubmed: 26441991
Nat Struct Mol Biol. 2019 Oct;26(10):880-889
pubmed: 31582846
J Mol Biol. 2017 Jan 20;429(2):295-307
pubmed: 27979648
Cancer Lett. 2021 Mar 31;501:247-262
pubmed: 33186656
J Steroid Biochem Mol Biol. 2005 Mar;94(4):337-46
pubmed: 15857753
J Biol Chem. 2012 Mar 9;287(11):7859-70
pubmed: 22241471
Science. 1988 Apr 15;240(4850):327-30
pubmed: 3353727
Cell. 1993 Nov 5;75(3):567-78
pubmed: 8221895
Theranostics. 2020 Feb 10;10(8):3451-3473
pubmed: 32206101
Nucleic Acids Res. 2020 Oct 9;48(18):10479-10499
pubmed: 32960212
Front Oncol. 2014 Aug 18;4:222
pubmed: 25184116
Neuropharmacology. 2020 Jun 15;170:108038
pubmed: 32151648
J Mol Cell Biol. 2020 Jul 3;12(6):462-476
pubmed: 31863092
Sci Rep. 2017 Dec 21;7(1):17993
pubmed: 29269946
Biochem Cell Biol. 2013 Dec;91(6):369-77
pubmed: 24219278
EMBO Rep. 2017 Aug;18(8):1442-1459
pubmed: 28615290
J Clin Invest. 2015 Dec;125(12):4529-43
pubmed: 26571401