Transforming growth factor‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p.
Adult
Aged
Apoptosis
/ genetics
Cell Line
Cerebral Hemorrhage
/ genetics
Child
Computational Biology
Female
Healthy Volunteers
Humans
Male
MicroRNAs
/ genetics
Microglia
/ drug effects
Middle Aged
NF-E2-Related Factor 2
/ antagonists & inhibitors
Neuroprotection
/ genetics
Signal Transduction
/ genetics
Thrombin
/ pharmacology
Transforming Growth Factor beta1
/ genetics
TGF‑β1
ceRNA
intracerebral hemorrhage
miRNA‑93‑5p
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
04
12
2020
accepted:
08
04
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
6
10
2021
Statut:
ppublish
Résumé
Intracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated neuroinflammation after ICH and promote functional recovery; however, the underlying mechanisms remain unclear. Non‑coding RNAs such as microRNAs (miRNAs) and competitive endogenous RNAs (ceRNAs) have surfaced as critical regulators in human disease. A known miR‑93 target, nuclear factor erythroid 2‑related factor 2 (Nrf2), has been shown to be neuroprotective after ICH. It was hypothesized that TGF‑β1 functions as a ceRNA that sponges miR‑93‑5p and thereby ameliorates ICH injury in the brain. Short interfering RNA (siRNA) was used to knock down TGF‑β1 and miR‑93 expression was also pharmacologically manipulated to elucidate the mechanistic association between miR‑93‑5p, Nrf2, and TGF‑β1 in an
Identifiants
pubmed: 33955515
doi: 10.3892/mmr.2021.12138
pii: 499
pmc: PMC8127068
doi:
pii:
Substances chimiques
MIRN93 microRNA, human
0
MicroRNAs
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Thrombin
EC 3.4.21.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Neurol Sci. 2016 Mar;37(3):353-9
pubmed: 26621360
Cold Spring Harb Perspect Biol. 2016 Jul 01;8(7):
pubmed: 27328871
Biochem Biophys Res Commun. 2018 Jan 29;496(1):184-190
pubmed: 29307821
J Clin Invest. 2017 Jan 3;127(1):280-292
pubmed: 27893460
Cell. 2011 Aug 5;146(3):353-8
pubmed: 21802130
FASEB J. 2013 Mar;27(3):907-19
pubmed: 23180826
Cell. 1993 Dec 17;75(6):1107-17
pubmed: 7505203
Stroke. 2015 Jul;46(7):1923-8
pubmed: 25977275
Mol Ther Nucleic Acids. 2018 Jun 1;11:345-353
pubmed: 29858070
Biol Psychiatry. 2018 Mar 1;83(5):395-405
pubmed: 28965984
Cochrane Database Syst Rev. 2018 Apr 17;4:CD005951
pubmed: 29664991
Am J Physiol Renal Physiol. 2006 Nov;291(5):F1070-7
pubmed: 16720864
J Neuroinflammation. 2017 Jun 29;14(1):132
pubmed: 28662718
J Pharmacol Sci. 2018 Apr;136(4):218-227
pubmed: 29551286
Exp Neurol. 2019 Jan;311:182-193
pubmed: 30291853
Mol Ther Nucleic Acids. 2017 Dec 15;9:440-451
pubmed: 29246322
Immunol Res. 2017 Oct;65(5):987-994
pubmed: 28845509
Neurobiol Dis. 2001 Dec;8(6):1057-68
pubmed: 11741401
Tumour Biol. 2016 Apr;37(4):5645-51
pubmed: 26581907
Neural Regen Res. 2016 Oct;11(10):1549-1552
pubmed: 27904475
Iran Biomed J. 2018 Jun 03;22(6):367-73
pubmed: 29859516
Nucleic Acids Res. 2011 Mar;39(6):2393-403
pubmed: 21075793
Am J Respir Cell Mol Biol. 2014 Jun;50(6):1144-55
pubmed: 24433094
Front Bioeng Biotechnol. 2020 Apr 29;8:334
pubmed: 32411683
Mol Cancer. 2014 Mar 08;13:51
pubmed: 24606633
Ann Clin Transl Neurol. 2014 Apr 1;1(4):258-271
pubmed: 24741667
F1000Res. 2014 Jul 01;3:153
pubmed: 25254104
PLoS One. 2010 Jul 23;5(7):e11746
pubmed: 20668522
Biochim Biophys Acta. 2008 Apr;1782(4):197-228
pubmed: 18313409
Cell. 1993 Dec 3;75(5):843-54
pubmed: 8252621
Int J Clin Exp Pathol. 2015 Sep 01;8(9):10156-63
pubmed: 26617723
Medicina (B Aires). 1970 Sep;30:Suppl 1:3-7
pubmed: 5527264
Drug Des Devel Ther. 2015 Nov 17;9:5973-86
pubmed: 26604696
J Neurochem. 2015 Apr;133(1):144-52
pubmed: 25328080
Cell. 2009 Jan 23;136(2):215-33
pubmed: 19167326
Drug Des Devel Ther. 2020 Sep 22;14:3853-3864
pubmed: 33061292
Stroke. 2007 Dec;38(12):3280-6
pubmed: 17962605
Clin Dev Immunol. 2013;2013:746068
pubmed: 24223607
Neuron. 2003 Dec 18;40(6):1133-45
pubmed: 14687548
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
N Engl J Med. 2001 May 10;344(19):1450-60
pubmed: 11346811
J Neuroinflammation. 2017 Jun 13;14(1):119
pubmed: 28610608
Cell. 1993 Mar 26;72(6):903-17
pubmed: 8384533
Neurochem Res. 2016 Oct;41(10):2627-2635
pubmed: 27300700
BMC Neurosci. 2008 Dec 10;9:117
pubmed: 19077183
J Stroke Cerebrovasc Dis. 2016 Mar;25(3):549-55
pubmed: 26683593
Cell Mol Neurobiol. 2003 Oct;23(4-5):539-50
pubmed: 14514014
Mol Neurobiol. 2016 Mar;53(2):1310-1321
pubmed: 25631713
Carcinogenesis. 2013 May;34(5):1165-72
pubmed: 23492819
J Neuroimmunol. 1997 Jul;77(1):45-50
pubmed: 9209267