Regenerated interneurons integrate into locomotor circuitry following spinal cord injury.
Neurogenesis
Regeneration
Spinal cord injury
Spinal interneurons
Zebrafish
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
22
12
2020
revised:
14
04
2021
accepted:
29
04
2021
pubmed:
7
5
2021
medline:
12
10
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Whereas humans and other adult mammals lack the ability to regain locomotor function after spinal cord injury, zebrafish are able to recover swimming behavior even after complete spinal cord transection. We have previously shown that zebrafish larvae regenerate lost spinal cord neurons within 9 days post-injury (dpi), but it is unknown whether these neurons are physiologically active or integrate into functional circuitry. Here we show that genetically defined premotor interneurons are regenerated in injured spinal cord segments as functional recovery begins. Further, we show that these newly-generated interneurons receive excitatory input and fire synchronously with motor output by 9 dpi. Taken together, our data indicate that regenerative neurogenesis in the zebrafish spinal cord produces interneurons with the ability to integrate into existing locomotor circuitry.
Identifiants
pubmed: 33957107
pii: S0014-4886(21)00143-6
doi: 10.1016/j.expneurol.2021.113737
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113737Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.