Cation-π Interactions and their Functional Roles in Membrane Proteins.
GPCR
cation-π interactions
computational chemistry
genetic code expansion
ion channels
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
received:
18
03
2021
revised:
27
04
2021
accepted:
27
04
2021
pubmed:
7
5
2021
medline:
21
10
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Cation-π interactions arise as a result of strong attractive forces between positively charged entities and the π-electron cloud of aromatic groups. The physicochemical characteristics of cation-π interactions are particularly well-suited to the dual hydrophobic/hydrophilic environment of membrane proteins. As high-resolution structural data of membrane proteins bring molecular features into increasingly sharper view, cation-π interactions are gaining traction as essential contributors to membrane protein chemistry, function, and pharmacology. Here we review the physicochemical properties of cation-π interactions and present several prominent examples which demonstrate significant roles for this specialized biological chemistry.
Identifiants
pubmed: 33957146
pii: S0022-2836(21)00249-7
doi: 10.1016/j.jmb.2021.167035
pmc: PMC8338773
mid: NIHMS1702731
pii:
doi:
Substances chimiques
Cations
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
167035Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM122420
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL149184
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM104601
Pays : United States
Organisme : NINDS NIH HHS
ID : R24 NS104617
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM106569
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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