No pressure, no diamonds? - Static vs. dynamic compressive in-situ loading to evaluate human articular cartilage functionality by functional MRI.
Cartilage
Dynamic
Loading
Static
T1ρ
Journal
Journal of the mechanical behavior of biomedical materials
ISSN: 1878-0180
Titre abrégé: J Mech Behav Biomed Mater
Pays: Netherlands
ID NLM: 101322406
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
09
10
2020
revised:
22
03
2021
accepted:
19
04
2021
pubmed:
7
5
2021
medline:
1
7
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Biomechanical Magnetic Resonance Imaging (MRI) of articular cartilage, i.e. its imaging under loading, is a promising diagnostic tool to assess the tissue's functionality in health and disease. This study aimed to assess the response to static and dynamic loading of histologically intact cartilage samples by functional MRI and pressure-controlled in-situ loading. To this end, 47 cartilage samples were obtained from the medial femoral condyles of total knee arthroplasties (from 24 patients), prepared to standard thickness, and placed in a standard knee joint in a pressure-controlled whole knee-joint compressive loading device. Cartilage samples' responses to static (i.e. constant), dynamic (i.e. alternating), and no loading, i.e. free-swelling conditions, were assessed before (δ
Identifiants
pubmed: 33957568
pii: S1751-6161(21)00240-X
doi: 10.1016/j.jmbbm.2021.104558
pii:
doi:
Substances chimiques
Diamond
7782-40-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104558Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.