Generation of clinical
Clinical dosimetry
DosiTest
GATE Monte Carlo modelling
SPECT/CT
Journal
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
03
12
2020
revised:
04
03
2021
accepted:
06
04
2021
pubmed:
7
5
2021
medline:
29
6
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Patient-specific dosimetry in MRT relies on quantitative imaging, pharmacokinetic assessment and absorbed dose calculation. The DosiTest project was initiated to evaluate the uncertainties associated with each step of the clinical dosimetry workflow through a virtual multicentric clinical trial. This work presents the generation of simulated clinical SPECT datasets based on GATE Monte Carlo modelling with its corresponding experimental CT image, which can subsequently be processed by commercial image workstations. This study considers a therapy cycle of 6.85 GBq Gamma index passing rate (2% - 1 pixel criteria) between 95 and 98% and average gamma between 0.28 and 0.35 among different time points revealed high similarity between simulated and experimental images. Image reconstruction of the simulated projections was successful on HERMES and Xeleris workstations, a major step forward for the initiation of a multicentric virtual clinical dosimetry trial based on simulated SPECT/CT images. Realistic
Identifiants
pubmed: 33957577
pii: S1120-1797(21)00158-7
doi: 10.1016/j.ejmp.2021.04.002
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-31Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.