Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
15
12
2020
accepted:
27
03
2021
revised:
18
02
2021
pubmed:
8
5
2021
medline:
3
11
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a better understanding of the mechanisms behind obese susceptibility to infection is imperative. Altered immune cell metabolism and function are often perceived as a key causative factor of dysregulated inflammation. However, the contribution of adipocytes, the dominantly altered cell type in obesity with broad inflammatory properties, to infectious disease pathogenesis remains largely ignored. Thus, skewing of adipocyte-intrinsic cellular metabolism may lead to the development of pathogenic inflammatory adipocytes, which shape the overall immune responses by contributing to either premature immunosenescence, delayed hyperinflammation, or cytokine storm in infections. In this review, we discuss the underappreciated contribution of adipocyte cellular metabolism and adipocyte-produced mediators on immune system modulation and how such interplay may modify disease susceptibility and pathogenesis of influenza and SARS-CoV-2 infections in obese individuals.
Identifiants
pubmed: 33958704
doi: 10.1038/s41385-021-00404-8
pii: S1933-0219(22)00218-5
pmc: PMC8100369
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224-1234Subventions
Organisme : Department of Defense
ID : W81XWH2010392
Organisme : BLRD VA
ID : I01 BX004630
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133797
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM063483
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139829
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106269
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099222
Pays : United States
Informations de copyright
© 2021. The Author(s).
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