Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.

Animals Continuous Positive Airway Pressure Humans Infant, Newborn Infant, Premature Mice Mice, Knockout RNA, Small Interfering Receptors, Calcium-Sensing / genetics Respiratory Sounds

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
05 2022
Historique:
received: 18 11 2020
accepted: 05 04 2021
revised: 15 03 2021
pubmed: 8 5 2021
medline: 18 6 2022
entrez: 7 5 2021
Statut: ppublish

Résumé

Continuous positive airway pressure (CPAP) in preterm infants is initially beneficial, but animal models suggest longer term detrimental airway effects towards asthma. We used a neonatal CPAP mouse model and human fetal airway smooth muscle (ASM) to investigate the role of extracellular calcium-sensing receptor (CaSR) in these effects. Newborn wild type and smooth muscle-specific CaSR CPAP increased airway reactivity in WT but not CaSR These data implicate CaSR in CPAP effects on airway function with implications for wheezing in former preterm infants. Neonatal CPAP increases airway reactivity to bronchoconstrictor agonist. CPAP increases smooth muscle expression of the extracellular calcium-sensing receptor (CaSR). Inhibition or absence of CaSR blunts CPAP effects on contractility. These data suggest a causal/contributory role for CaSR in stretch effects on the developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.

Sections du résumé

BACKGROUND
Continuous positive airway pressure (CPAP) in preterm infants is initially beneficial, but animal models suggest longer term detrimental airway effects towards asthma. We used a neonatal CPAP mouse model and human fetal airway smooth muscle (ASM) to investigate the role of extracellular calcium-sensing receptor (CaSR) in these effects.
METHODS
Newborn wild type and smooth muscle-specific CaSR
RESULTS
CPAP increased airway reactivity in WT but not CaSR
CONCLUSIONS
These data implicate CaSR in CPAP effects on airway function with implications for wheezing in former preterm infants.
IMPACT
Neonatal CPAP increases airway reactivity to bronchoconstrictor agonist. CPAP increases smooth muscle expression of the extracellular calcium-sensing receptor (CaSR). Inhibition or absence of CaSR blunts CPAP effects on contractility. These data suggest a causal/contributory role for CaSR in stretch effects on the developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.

Identifiants

DOI: 10.1038/s41390-021-01540-4 PMID: 33958714 PMC: PMC8571113
pubmed: 33958714
doi: 10.1038/s41390-021-01540-4
pii: 10.1038/s41390-021-01540-4
pmc: PMC8571113
mid: NIHMS1692836
doi:

Substances chimiques

CASR protein, mouse 0
RNA, Small Interfering 0
Receptors, Calcium-Sensing 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1391-1398

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL107147
Pays : United States
Organisme : NIH HHS
ID : S10 OD024996
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG070721
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL056470
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004835
Pays : United States
Organisme : BLRD VA
ID : I01 BX005851
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138402
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

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Auteurs

Catherine A Mayer (CA)

Department of Pediatrics, Division of Neonatology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.

Benjamin Roos (B)

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Jacob Teske (J)

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Natalya Wells (N)

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Richard J Martin (RJ)

Department of Pediatrics, Division of Neonatology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.

Wenhan Chang (W)

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Christina M Pabelick (CM)

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Y S Prakash (YS)

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. Prakash.ys@mayo.edu.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Prakash.ys@mayo.edu.

Peter M MacFarlane (PM)

Department of Pediatrics, Division of Neonatology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA. pmm71@case.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Thérapeutique › Thérapie respiratoire › Ventilation artificielle › Ventilation à pression positive › Ventilation en pression positive continue › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs-détecteurs du calcium › Calcium-sensing receptor and CPAP-induced...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Bruits respiratoires › Calcium-sensing receptor and CPAP-induced...