Pathophysiological Bases of Comorbidity in Migraine.
CNS disorders
energetic balance
migraine threshold
thalamocortical network dysexcitability
trigeminovascular system
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
12
2020
accepted:
23
02
2021
entrez:
7
5
2021
pubmed:
8
5
2021
medline:
8
5
2021
Statut:
epublish
Résumé
Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors.
Identifiants
pubmed: 33958992
doi: 10.3389/fnhum.2021.640574
pmc: PMC8093831
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
640574Informations de copyright
Copyright © 2021 Altamura, Corbelli, de Tommaso, Di Lorenzo, Di Lorenzo, Di Renzo, Filippi, Jannini, Messina, Parisi, Parisi, Pierelli, Rainero, Raucci, Rubino, Sarchielli, Li, Vernieri, Vollono and Coppola.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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