Pathologic and molecular features of hepatocellular carcinoma: An update.
Fibrolamellar
Hepatocellular carcinoma subtypes
Macrotrabecular massive
Molecular alterations
Pathology
Steatohepatitic
Journal
World journal of hepatology
ISSN: 1948-5182
Titre abrégé: World J Hepatol
Pays: United States
ID NLM: 101532469
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
received:
20
12
2020
revised:
27
01
2021
accepted:
31
03
2021
entrez:
7
5
2021
pubmed:
8
5
2021
medline:
8
5
2021
Statut:
ppublish
Résumé
Morphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremely aggressive with vascular invasion, early recurrence, and worst outcomes. Several targeted treatments are now being considered in HCC, and the reporting of subtypes may be quite useful for personalized therapeutic purpose. This manuscript reviews the recently identified histomorphological subtypes and molecular alterations in HCC.
Identifiants
pubmed: 33959223
doi: 10.4254/wjh.v13.i4.393
pmc: PMC8080551
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
393-410Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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