No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004-2017, Paris, France).
candidemia
echinocandins
epidemiology
fluconazole
fungemia
hematological malignancy
intensive care unit
solid cancer
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
12
2020
accepted:
15
03
2021
entrez:
7
5
2021
pubmed:
8
5
2021
medline:
8
5
2021
Statut:
epublish
Résumé
Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia. We analyzed the individual clinical and microbiological data collected through the active surveillance program on yeast fungemia (YEASTS program, 2004-2016, Paris area, France) within 14 University Hospitals. The cohort included 3,092 patients [male:female ratio: 1.56; median age 61.0 years (IQR: 23.8)]. The mean mortality rate within 30 days was 38.5% (1,103/2,868) and significantly higher in intensive care units (690/1,358, 50.8%) than outside (413/1,510, 27.4%,
Identifiants
pubmed: 33959624
doi: 10.3389/fmed.2021.641965
pmc: PMC8093410
doi:
Types de publication
Journal Article
Langues
eng
Pagination
641965Informations de copyright
Copyright © 2021 Bretagne, Desnos-Ollivier, Sitbon, Lortholary, Che, Dromer and Participants of the YEASTS.
Déclaration de conflit d'intérêts
SB has received travel grant from Pfizer in 2018 and has served on scientific advisory board for Gilead until 2018. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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