Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect.
cerium oxide nanoparticles
hypergravity
microgravity
planarians
stem cells
Journal
Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
12
04
2021
received:
11
01
2021
accepted:
26
04
2021
pubmed:
8
5
2021
medline:
17
3
2022
entrez:
7
5
2021
Statut:
ppublish
Résumé
Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles.
Identifiants
pubmed: 33960131
doi: 10.1002/jbm.a.37215
pmc: PMC8518838
doi:
Substances chimiques
Cerium
30K4522N6T
ceric oxide
619G5K328Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2322-2333Informations de copyright
© 2021 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.
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