Peripheral BDNF levels in psychiatric patients with and without a history of suicide attempt: A systematic review and meta-analysis.

Biomarkers / blood Brain-Derived Neurotrophic Factor / blood Depressive Disorder, Major / complications Humans Suicide, Attempted / statistics & numerical data
Biomarker Brain-derived neurotrophic factor Plasma Serum Suicide

Journal

Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617

Informations de publication

Date de publication:
20 12 2021
Historique:
received: 08 03 2021
revised: 20 04 2021
accepted: 02 05 2021
pubmed: 8 5 2021
medline: 16 2 2022
entrez: 7 5 2021
Statut: ppublish

Résumé

Psychiatric patients are at increased risk of attempting suicide. Several potential biomarkers of suicide risk have been proposed with inconsistent findings. The present paper aimed to evaluate differences in peripheral BDNF levels between psychiatric patients with and without a history of suicide attempts. We conducted a systematic review and meta-analysis following the PRISMA guidelines. Relevant papers published up to January 5, 2021 were identified searching the electronic databases Web of Knowledge Thirteen studies met inclusion criteria. Overall, no significant differences in BDNF levels between the two groups were found (13 studies, n = 1340, Hedge's g = -0.21, 95% CI -0.44 to 0.02). Heterogeneity was substantial (I The utility of BDNF as a biomarker of suicide attempts in psychiatric patients appears limited to its plasma concentration. Although caution interpretation is needed, our findings may represent a starting point for the design of rigorous case-control studies exploring the association between neurotrophins and suicidal behaviors.

Identifiants

DOI: 10.1016/j.pnpbp.2021.110342 PMID: 33961965
pubmed: 33961965
pii: S0278-5846(21)00101-9
doi: 10.1016/j.pnpbp.2021.110342
pii:
doi:

Substances chimiques

Biomarkers 0
Brain-Derived Neurotrophic Factor 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

110342

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Laura Fusar-Poli (L)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy. Electronic address: laura.fusarpoli@gmail.com.

Andrea Aguglia (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Andrea Amerio (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Psychiatry, Tufts University, Boston, MA, USA.

Laura Orsolini (L)

Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Virginio Salvi (V)

Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy.

Gianluca Serafini (G)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Umberto Volpe (U)

Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy.

Mario Amore (M)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Eugenio Aguglia (E)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Peripheral BDNF levels in psychiatric patients...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Peripheral BDNF levels in psychiatric patients...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Peripheral BDNF levels in psychiatric patients...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Peripheral BDNF levels in psychiatric patients...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Suicide › Tentative de suicide › Peripheral BDNF levels in psychiatric patients...