Insulin-like growth factors: Ligands, binding proteins, and receptors.
Cancer
Growth
Insulin-like growth factor binding proteins
Insulin-like growth factor receptors
Insulin-like growth factors
Metabolism
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
24
11
2020
revised:
09
04
2021
accepted:
28
04
2021
pubmed:
8
5
2021
medline:
11
3
2022
entrez:
7
5
2021
Statut:
ppublish
Résumé
The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states. Insulin and insulin receptors are the focus of other chapters in this series and will therefore not be discussed further. Here we review the basic components of the IGF system, their role in normal physiology and in critical pathology's. While this review concentrates on the role of IGFs in human physiology, animal models have been essential in providing understanding of the IGF system, and its regulation, and are briefly described. IGF-I has effects via the circulation and locally within tissues to regulate cellular growth, differentiation, and survival, thereby controlling overall body growth. IGF-II levels are highest prenatally when it has important effects on growth. In adults, IGF-II plays important tissue-specific roles, including the maintenance of stem cell populations. Although the IGF-IR is closely related to the IR it has distinct physiological roles both on the cell surface and in the nucleus. The M6P/IGF-IIR, in contrast, is distinct and acts as a scavenger by mediating internalization and degradation of IGF-II. The IGFBPs bind IGF-I and IGF-II in the circulation to prolong their half-lives and modulate tissue access, thereby controlling IGF function. IGFBPs also have IGF ligand-independent cell effects.
Sections du résumé
BACKGROUND
The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
SCOPE OF REVIEW
Insulin and insulin receptors are the focus of other chapters in this series and will therefore not be discussed further. Here we review the basic components of the IGF system, their role in normal physiology and in critical pathology's. While this review concentrates on the role of IGFs in human physiology, animal models have been essential in providing understanding of the IGF system, and its regulation, and are briefly described.
MAJOR CONCLUSIONS
IGF-I has effects via the circulation and locally within tissues to regulate cellular growth, differentiation, and survival, thereby controlling overall body growth. IGF-II levels are highest prenatally when it has important effects on growth. In adults, IGF-II plays important tissue-specific roles, including the maintenance of stem cell populations. Although the IGF-IR is closely related to the IR it has distinct physiological roles both on the cell surface and in the nucleus. The M6P/IGF-IIR, in contrast, is distinct and acts as a scavenger by mediating internalization and degradation of IGF-II. The IGFBPs bind IGF-I and IGF-II in the circulation to prolong their half-lives and modulate tissue access, thereby controlling IGF function. IGFBPs also have IGF ligand-independent cell effects.
Identifiants
pubmed: 33962049
pii: S2212-8778(21)00090-9
doi: 10.1016/j.molmet.2021.101245
pmc: PMC8513159
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor Binding Proteins
0
Ligands
0
Somatomedins
0
Receptor, Insulin
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101245Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier GmbH.. All rights reserved.
Références
Nature. 2020 Jul;583(7817):615-619
pubmed: 32494007
J Mol Endocrinol. 2018 Jul;61(1):T69-T86
pubmed: 29535161
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7324-9
pubmed: 10377413
Structure. 2020 Jul 7;28(7):786-798.e6
pubmed: 32459985
Pancreas. 1997 Nov;15(4):367-73
pubmed: 9361090
PLoS One. 2015 Feb 13;10(2):e0117745
pubmed: 25680198
FASEB J. 2003 Nov;17(14):2068-81
pubmed: 14597676
J Biol Chem. 1997 Aug 15;272(33):20572-6
pubmed: 9252371
J Exp Clin Cancer Res. 2019 Jan 9;38(1):13
pubmed: 30626422
J Cell Biochem. 2002;84(4):784-94
pubmed: 11835403
Mol Cell Biol. 2002 Apr;22(7):2345-65
pubmed: 11884618
J Invest Dermatol. 2008 Jun;128(6):1535-44
pubmed: 18200066
Miner Electrolyte Metab. 1997;23(3-6):157-60
pubmed: 9387107
J Cell Biol. 1993 May;121(3):679-87
pubmed: 7683690
Clin Endocrinol (Oxf). 1990 Feb;32(2):229-39
pubmed: 1693321
J Clin Oncol. 2014 Jul 1;32(19):2059-66
pubmed: 24888810
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6868-73
pubmed: 10823924
J Endocrinol. 2016 Jul;230(1):R13-25
pubmed: 27113851
Mol Cell Endocrinol. 2020 Dec 1;518:110967
pubmed: 32739295
Adv Exp Med Biol. 1993;343:215-26
pubmed: 7514335
Development. 2017 Oct 1;144(19):3533-3546
pubmed: 28974642
J Biol Chem. 2015 May 1;290(18):11578-90
pubmed: 25787077
Adv Biochem Psychopharmacol. 1980;21:489-97
pubmed: 6246756
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2684-90
pubmed: 17916769
J Cell Sci. 2002 Nov 15;115(Pt 22):4293-303
pubmed: 12376561
Growth Regul. 1993 Mar;3(1):53-6
pubmed: 7683531
Nature. 1996 Nov 7;384(6604):33
pubmed: 8900272
J Biol Chem. 2006 Sep 8;281(36):25869-74
pubmed: 16831875
Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):30-8
pubmed: 24322424
Mol Endocrinol. 2004 Oct;18(10):2502-12
pubmed: 15205474
Mol Cell Endocrinol. 2020 Dec 1;518:111006
pubmed: 32861700
Endocr Rev. 2019 Apr 1;40(2):476-505
pubmed: 30265312
Endocr Rev. 2017 Oct 1;38(5):379-431
pubmed: 28973479
Horm Res. 2001;55 Suppl 2:68-72
pubmed: 11684881
Cell. 1993 Oct 8;75(1):73-82
pubmed: 8402902
Cell. 2009 Dec 11;139(6):1157-69
pubmed: 20005808
Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E50-8
pubmed: 16449294
Biochem Insights. 2019 Apr 17;12:1178626419842176
pubmed: 31024217
Stem Cell Res Ther. 2017 Aug 30;8(1):192
pubmed: 28854965
Mol Endocrinol. 1996 Jun;10(6):631-41
pubmed: 8776723
J Clin Endocrinol Metab. 2004 May;89(5):2382-9
pubmed: 15126567
J Med Genet. 2012 Sep;49(9):547-53
pubmed: 22844132
Endocr Rev. 2019 Feb 1;40(1):236-267
pubmed: 30215690
Mol Neurobiol. 2017 May;54(4):2636-2658
pubmed: 26993302
J Clin Endocrinol Metab. 1983 Feb;56(2):376-83
pubmed: 6337177
Cancer Res. 2018 Jul 1;78(13):3497-3509
pubmed: 29735545
Neurobiol Aging. 2010 Feb;31(2):224-43
pubmed: 18479783
J Mol Endocrinol. 2018 Jul;61(1):T11-T28
pubmed: 29255001
Mol Cell Endocrinol. 2020 Dec 1;518:111035
pubmed: 32941924
J Mol Endocrinol. 2015 Feb;54(1):R1-13
pubmed: 25351818
Growth Horm IGF Res. 2016 Apr;27:41-45
pubmed: 26925766
Clin Endocrinol (Oxf). 1988 Dec;29(6):667-75
pubmed: 2476266
Cells. 2019 Aug 14;8(8):
pubmed: 31416218
Oncogene. 2007 Aug 30;26(40):5966-72
pubmed: 17369847
Genes Dev. 1993 Dec;7(12B):2609-17
pubmed: 8276243
Endocr Pract. 2015 Dec;21(12):1395-402
pubmed: 26401581
J Biol Chem. 2007 Apr 13;282(15):11329-38
pubmed: 17303558
Cells. 2019 Oct 06;8(10):
pubmed: 31590432
J Lab Clin Med. 1957 Jun;49(6):825-36
pubmed: 13429201
Cancer Res. 1996 Sep 1;56(17):4013-20
pubmed: 8752172
Endocrinology. 2013 Nov;154(11):4146-57
pubmed: 23981772
Endocr Rev. 2009 Oct;30(6):586-623
pubmed: 19752219
Sci Signal. 2010 Feb 09;3(108):ra10
pubmed: 20145208
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1253-8
pubmed: 9448318
Int J Biochem Cell Biol. 2009 Apr;41(4):771-83
pubmed: 18775791
Nature. 2016 May 02;534(7605):47-54
pubmed: 27135926
Diabetes. 2007 Feb;56(2):285-94
pubmed: 17259371
Semin Cell Dev Biol. 2017 Feb;62:133-141
pubmed: 28027946
J Clin Endocrinol Metab. 1997 Jun;82(6):1863-8
pubmed: 9177397
Nature. 2003 Jan 9;421(6919):182-7
pubmed: 12483226
Nat Commun. 2020 Feb 7;11(1):764
pubmed: 32034154
Biol Chem. 2007 Aug;388(8):859-63
pubmed: 17655506
Exp Cell Res. 1999 Apr 10;248(1):44-57
pubmed: 10094812
J Biol Chem. 1998 Mar 20;273(12):7162-8
pubmed: 9507031
Growth Horm IGF Res. 2020 Jun;52:101319
pubmed: 32339897
Growth Horm IGF Res. 2019 Apr;45:6-16
pubmed: 30735831
Front Endocrinol (Lausanne). 2019 Feb 01;10:27
pubmed: 30774624
NPJ Precis Oncol. 2017;1:
pubmed: 29152592
Cells. 2020 Aug 06;9(8):
pubmed: 32781621
Cell Mol Life Sci. 2014 Jul;71(13):2403-27
pubmed: 24276851
FEBS Lett. 1992 Aug 3;307(3):379-82
pubmed: 1379546
Endocr Rev. 2002 Dec;23(6):824-54
pubmed: 12466191
FASEB J. 2004 Sep;18(12):1456-8
pubmed: 15247143
Endocrinology. 1990 Sep;127(3):1078-86
pubmed: 1696879
Nat Genet. 1995 Dec;11(4):447-9
pubmed: 7493029
Mol Cell Biol. 2012 Oct;32(20):4116-30
pubmed: 22869525
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8387-92
pubmed: 18550829
Exp Hematol. 1996 Apr;24(5):622-7
pubmed: 8605967
Endocrinology. 1999 Mar;140(3):1319-28
pubmed: 10067859
Cells. 2020 Apr 29;9(5):
pubmed: 32365498
Clin Cancer Res. 2008 Oct 15;14(20):6364-70
pubmed: 18927274
Cell. 1993 Oct 8;75(1):59-72
pubmed: 8402901
Bioessays. 2015 Apr;37(4):389-97
pubmed: 25630923
Cell Metab. 2016 Jun 14;23(6):980-989
pubmed: 27304500
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10365-9
pubmed: 7524092
Nature. 1990 May 3;345(6270):78-80
pubmed: 2330056
Eur J Neurol. 2014 May;21(5):802-7
pubmed: 23551560
Int J Cancer. 2015 Nov 1;137(9):2243-52
pubmed: 25924852
Am J Respir Crit Care Med. 2020 May 1;201(9):1120-1134
pubmed: 32101461
Endocrinology. 2013 Oct;154(10):3753-63
pubmed: 23845322
Growth Horm IGF Res. 2015 Jun;25(3):103-7
pubmed: 25683897
J Biol Chem. 2011 Apr 22;286(16):14670-80
pubmed: 21372140
Trends Endocrinol Metab. 2003 May-Jun;14(4):176-81
pubmed: 12714278
Cancer Res. 1993 Mar 1;53(5):1102-6
pubmed: 8439954
J Cell Commun Signal. 2015 Jun;9(2):167-76
pubmed: 25617051
Mol Cell Endocrinol. 2021 Jan 1;519:111052
pubmed: 33068640
Ann Endocrinol (Paris). 2016 Jun;77(2):90-6
pubmed: 27155776
Gene. 2015 Sep 10;569(1):7-13
pubmed: 26074086
Trends Endocrinol Metab. 2009 May;20(4):153-62
pubmed: 19349193
Nat Rev Cancer. 2013 Oct;13(10):714-26
pubmed: 24060863
Lancet. 2004 Apr 24;363(9418):1346-53
pubmed: 15110491
Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E519-29
pubmed: 27406741
FASEB J. 2019 Jan;33(1):181-194
pubmed: 29932867
J Biol Chem. 2006 Oct 6;281(40):29962-71
pubmed: 16901893
J Clin Invest. 1994 May;93(5):2286-90
pubmed: 7514194
Bioessays. 2013 Nov;35(11):945-54, doi/10.1002/bies.201370111
pubmed: 24037759
Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1039-H1049
pubmed: 31518159
Int J Cancer. 2000 Nov 1;88(3):336-41
pubmed: 11054660
J Biol Chem. 2018 Mar 23;293(12):4324-4333
pubmed: 29414792
Cancer Res. 2020 Sep 15;80(18):4014-4021
pubmed: 32709735
Cell Mol Life Sci. 2007 Jul;64(14):1870-80
pubmed: 17593323
Cell. 1991 Feb 22;64(4):849-59
pubmed: 1997210
PLoS One. 2019 Jun 28;14(6):e0219155
pubmed: 31251794
Oncogene. 2012 May 31;31(22):2703-14
pubmed: 21963847
Endocrinology. 1990 Jul;127(1):497-9
pubmed: 1694498
J Biol Chem. 1991 Aug 25;266(24):15917-23
pubmed: 1651927
J Mol Endocrinol. 2011 Jun 17;47(1):R1-10
pubmed: 21498522
Nat Commun. 2018 Oct 24;9(1):4420
pubmed: 30356040
J Cell Biol. 2018 May 7;217(5):1643-1649
pubmed: 29453311
Endocrinology. 2011 Jun;152(6):2278-89
pubmed: 21505050
Hepatology. 1996 Apr;23(4):818-27
pubmed: 8666337
J Clin Endocrinol Metab. 1983 Feb;56(2):384-9
pubmed: 6185523
Endocrinology. 1998 Dec;139(12):4772-81
pubmed: 9832413
Nat Commun. 2018 Sep 21;9(1):3860
pubmed: 30242155
Clin Cancer Res. 2002 Oct;8(10):3259-69
pubmed: 12374697
Biochem Biophys Res Commun. 2000 Nov 11;278(1):38-43
pubmed: 11071852
Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1098-E1107
pubmed: 30040480
J Biol Chem. 2005 Sep 23;280(38):33076-82
pubmed: 16049009
J Alzheimers Dis. 2009;16(3):585-99
pubmed: 19276553
J Clin Endocrinol Metab. 1990 Oct;71(4):797-805
pubmed: 1698199
Growth Horm IGF Res. 2007 Aug;17(4):265-70
pubmed: 17412627
J Biol Chem. 1999 May 21;274(21):15262-70
pubmed: 10329736
Dement Geriatr Cogn Disord. 2015;39(5-6):251-6
pubmed: 25661865
Horm Metab Res. 2003 Nov-Dec;35(11-12):771-7
pubmed: 14710357
Front Endocrinol (Lausanne). 2021 Jan 29;11:620013
pubmed: 33584548
Cell Adh Migr. 2018;12(4):305-314
pubmed: 29486622
Oncogene. 1995 May 4;10(9):1725-9
pubmed: 7753549
J Clin Endocrinol Metab. 1990 Oct;71(4):806-16
pubmed: 1698200
Am J Kidney Dis. 2015 Feb;65(2):327-36
pubmed: 25151409
Endocrinology. 2000 Dec;141(12):4436-41
pubmed: 11108252
J Biol Chem. 1995 Jun 30;270(26):15639-43
pubmed: 7541045
Curr Med Chem. 2011;18(12):1740-50
pubmed: 21466477
Biofactors. 2020 Jul;46(4):563-578
pubmed: 32026557
J Natl Cancer Inst. 2012 Jul 3;104(13):975-81
pubmed: 22761272
J Biol Chem. 2010 Dec 31;285(53):41886-95
pubmed: 20940305
BMC Cancer. 2014 Feb 26;14:134
pubmed: 24571711
J Clin Endocrinol Metab. 1977 Nov;45(5):988-95
pubmed: 925145
Diabetes. 2017 Nov;66(11):2903-2914
pubmed: 28838971
Trends Neurosci. 2012 May;35(5):274-83
pubmed: 22341662
Nat Commun. 2019 Oct 8;10(1):4567
pubmed: 31594955
Immunity. 2020 Feb 18;52(2):275-294.e9
pubmed: 32075728
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6379-6384
pubmed: 30765523
J Biol Chem. 1989 Jul 5;264(19):11004-8
pubmed: 2472386
Circulation. 2016 Jun 7;133(23):2263-78
pubmed: 27154724
Endocr Rev. 1995 Apr;16(2):143-63
pubmed: 7540132
Neuroendocrinology. 2006;83(3-4):154-60
pubmed: 17047378
Stem Cell Reports. 2019 Apr 9;12(4):816-830
pubmed: 30905741
Mol Cancer Ther. 2010 Oct;9(10):2652-64
pubmed: 20924128
Am J Physiol. 1998 Apr;274(4):E744-50
pubmed: 9575837
Nat Commun. 2018 Feb 26;9(1):821
pubmed: 29483580
Endocr Rev. 1994 Jun;15(3):369-90
pubmed: 8076588
Horm Metab Res. 2003 Nov-Dec;35(11-12):778-85
pubmed: 14710358
J Biol Chem. 1995 Sep 22;270(38):22639-44
pubmed: 7673254
Acta Endocrinol (Copenh). 1989 Dec;121(6):753-8
pubmed: 2558477
Br J Cancer. 2017 Nov 21;117(11):1600-1606
pubmed: 28972962
Growth Horm IGF Res. 2016 Jun;28:26-42
pubmed: 26432542
N Engl J Med. 2015 Jul 23;373(4):349-56
pubmed: 26154720
Stem Cells. 2012 Jun;30(6):1265-76
pubmed: 22593020
J Biol Chem. 1999 Mar 5;274(10):6711-7
pubmed: 10037769
Oncogene. 2018 Jun;37(23):3131-3150
pubmed: 29540831
J Mol Endocrinol. 2004 Jun;32(3):859-68
pubmed: 15171717
Cancer Res. 2010 Aug 15;70(16):6412-9
pubmed: 20710042
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10553-7
pubmed: 7504269
J Mol Endocrinol. 2018 Jul;61(1):T1-T10
pubmed: 29844094
Growth Horm IGF Res. 1999 Apr;9(2):85-95
pubmed: 10373341