Ethanolic extract of
Achillea
acute lung injury
inflammation
lipopolysaccharide
tumor necrosis factor-alpha
Journal
Journal of complementary & integrative medicine
ISSN: 1553-3840
Titre abrégé: J Complement Integr Med
Pays: Germany
ID NLM: 101313855
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
received:
30
01
2021
accepted:
06
04
2021
pubmed:
8
5
2021
medline:
2
9
2022
entrez:
7
5
2021
Statut:
epublish
Résumé
Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. The ALI model was established via the intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW (150-300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were evaluated for inflammatory cell influx, level of tumor necrosis factor-α (TNF-α) and histopathological changes. The AW (150-300 mg/kg) treated mice showed lower inflammatory cells infiltration in BALF and TNF-α level when compared to the model group. In addition, LPS induced several pathological alterations such as edema, alveolar hemorrhage and inflammatory cell infiltration into the interstitium and alveolar spaces. Treatment with AW significantly reduced LPS-induced pathological injury. Taken together, the data here indicated that AW may be considered as a promising add-on therapy for ALI.
Identifiants
pubmed: 33962506
pii: jcim-2021-0045
doi: 10.1515/jcim-2021-0045
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Lipopolysaccharides
0
Plant Extracts
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-267Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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