Genetics of canine subvalvular aortic stenosis (SAS).
Aortic stenosis
Cardiac genetics
Congenital heart disease
Subaortic stenosis
Veterinary
Journal
Canine medicine and genetics
ISSN: 2662-9380
Titre abrégé: Canine Med Genet
Pays: England
ID NLM: 101763636
Informations de publication
Date de publication:
07 May 2021
07 May 2021
Historique:
received:
25
01
2021
accepted:
29
04
2021
entrez:
8
5
2021
pubmed:
9
5
2021
medline:
9
5
2021
Statut:
epublish
Résumé
Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands.
Identifiants
pubmed: 33962679
doi: 10.1186/s40575-021-00103-4
pii: 10.1186/s40575-021-00103-4
pmc: PMC8103588
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4Subventions
Organisme : American Kennel Club Canine Health Foundation
ID : American Kennel Club Canine Health Foundation
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