Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis.

Africa South of the Sahara Animals Cattle Cattle Diseases / drug therapy Trypanocidal Agents / administration & dosage Trypanosomiasis, African / drug therapy
African animal trypanosomiasis drug resistance drug use research standardization trypanocide

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
09 2021
Historique:
received: 29 01 2021
revised: 05 04 2021
accepted: 08 04 2021
pubmed: 9 5 2021
medline: 2 10 2021
entrez: 8 5 2021
Statut: ppublish

Résumé

Trypanocides are a key control component of African animal trypanosomiasis (AAT) in tsetse-infested areas of sub-Saharan Africa. While farmers are dependent upon trypanocides, recent research highlights their inappropriate and ineffective use, problems with drug quality, and treatment failure. There are currently gaps in knowledge and investment in inexpensive AAT diagnostics, understanding of drug resistance, and the effective use of trypanocides in the field. Without this important knowledge it is difficult to develop best practice and policy for existing drugs or to inform development and use of new drugs. There needs to be better understanding of the drivers and behavioural practices around trypanocide use so that they can be incorporated into sustainable solutions needed for the development of effective control of AAT.

Identifiants

DOI: 10.1016/j.pt.2021.04.007 PMID: 33962879
pubmed: 33962879
pii: S1471-4922(21)00087-8
doi: 10.1016/j.pt.2021.04.007
pii:
doi:

Substances chimiques

Trypanocidal Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

831-843

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S001034/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S00243X/1
Pays : United Kingdom
Organisme : BLRD VA
ID : B/S000143/2
Pays : United States
Organisme : WETP NIH HHS
ID : 104111/Z/14/Z
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20002173
Pays : United Kingdom

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Shauna Richards (S)

Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: shauna.richards@glasgow.ac.uk.

Liam J Morrison (LJ)

Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.

Steve J Torr (SJ)

Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.

Michael P Barrett (MP)

Wellcome Centre for Integrative Parasitology, Institute of Infection, Inflammation & Immunity, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

Oliver Manangwa (O)

Vector and Vector Borne Disease Institute, Tanga, Tanzania.

Furaha Mramba (F)

Tanzania Veterinary Laboratory Agency, Dar Es Salaam, Tanzania.

Harriet Auty (H)

Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Pharma to farmer: field challenges of...
questionsmedicales.fr › Eucaryotes › Animaux › Pharma to farmer: field challenges of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Pharma to farmer: field challenges of...
questionsmedicales.fr › Maladies de l'animal › Maladies des bovins › Pharma to farmer: field challenges of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Pharma to farmer: field challenges of...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie du sommeil › Pharma to farmer: field challenges of...