Cold-induction of afadin in brown fat supports its thermogenic capacity.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
21
09
2020
accepted:
14
04
2021
entrez:
8
5
2021
pubmed:
9
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
The profound energy-expending nature of brown adipose tissue (BAT) thermogenesis makes it an attractive target tissue to combat obesity-associated metabolic disorders. While cold exposure is the strongest inducer of BAT activity, the temporal mechanisms tuning BAT adaptation during this activation process are incompletely understood. Here we show that the scaffold protein Afadin is dynamically regulated by cold in BAT, and participates in cold acclimation. Cold exposure acutely increases Afadin protein levels and its phosphorylation in BAT. Knockdown of Afadin in brown pre-adipocytes does not alter adipogenesis but restricts β
Identifiants
pubmed: 33963248
doi: 10.1038/s41598-021-89207-2
pii: 10.1038/s41598-021-89207-2
pmc: PMC8105362
doi:
Substances chimiques
Afdn protein, mouse
0
Myosins
EC 3.6.4.1
Kinesins
EC 3.6.4.4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9794Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK102898
Pays : United States
Organisme : Novo Nordisk Foundation Center for Basic Metabolic Research
ID : NNF18CC0034900
Organisme : NIDDK NIH HHS
ID : P30DK036836
Pays : United States
Organisme : Sundhed og Sygdom, Det Frie Forskningsråd
ID : DFF 5053-00112
Organisme : NIH HHS
ID : R01DK077097
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : Novo Nordisk Fonden
ID : NNF15OC0016510
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