Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component.
canine
histopathology
immunohistochemistry
p63
prostate carcinoma
uroplakin
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
31
03
2021
received:
09
07
2020
accepted:
06
05
2021
pubmed:
9
5
2021
medline:
1
4
2022
entrez:
8
5
2021
Statut:
ppublish
Résumé
A limited number of species, including men and dogs, spontaneously develop prostate cancer (PC). The histological and molecular relevance of canine PC as a model for the disease in men remains controversial. To address this challenge, this study aimed to assess the histomorphology and expression of basal cell, urothelial and neuroendocrine markers [p63, high molecular weight cytokeratin (HMWCK), Uroplakin 3 (UPIII), neuron-specific enolase (NSE)] in canine PC (n = 41). Based on histomorphology, 10/41 (24%), 21/41 (51%) and 9/41 (22%) were classified as adenocarcinoma (AC), urothelial carcinoma (UC), and mixed carcinoma, respectively. Tumour inflammation was common, frequently severe [20/41 (49%)], and associated with neutering (p < .02) and urothelial differentiation (p < .02). Most (36/40, 90%) cancers contained only rare cells with basal cell marker expression or were negative. The expression of UPIII was absent or weak in the majority (33/38, 87%) of tumours, with moderate to strong staining in the remaining cases. NSE expression in PC was rare and limited to 2/14 (14%) cases. Tumour extension into benign ducts and glands was a common finding with presence in 17/39 (44%) of carcinomas with and without urothelial differentiation. In conclusion, we confirm that canine PC is characterized by absent or weak expression of basal cell and urothelial markers. Although rare, NSE expression, potentially indicating neuroendocrine differentiation, is reported for the first time in canine PCa. Intraductal carcinoma of the prostate with concurrent invasive PCa (IDCP-inv) is a frequent, not previously described, finding in dogs with PC.
Identifiants
pubmed: 33963663
doi: 10.1111/vco.12704
pmc: PMC9292867
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-49Subventions
Organisme : Petplan Charitable Trust
ID : 542127
Organisme : University of Nottingham Interdisciplinary Centre for Analytical Science (UNICAS)
Informations de copyright
© 2021 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.
Références
Am J Surg Pathol. 2014 Jun;38(6):756-67
pubmed: 24705311
Urol Clin North Am. 2016 Aug;43(3):279-88
pubmed: 27476121
Mod Pathol. 2018 Jan;31(S1):S71-79
pubmed: 29297491
J Pathol Transl Med. 2016 Sep;50(5):345-54
pubmed: 27498545
Clin Cancer Res. 2003 Nov 15;9(15):5501-7
pubmed: 14654529
Transl Androl Urol. 2017 Jun;6(3):538-546
pubmed: 28725597
Am J Surg Pathol. 2014 Aug;38(8):e6-e19
pubmed: 25029122
Appl Immunohistochem Mol Morphol. 2010 Oct;18(5):401-10
pubmed: 20505509
Prostate. 2000 Oct 1;45(2):173-83
pubmed: 11027417
Am J Clin Pathol. 2006 May;125(5):675-81
pubmed: 16707367
Int J Urol. 2015 Feb;22(2):140-5
pubmed: 25358604
Endocr Rev. 1987 Aug;8(3):338-62
pubmed: 3308446
Vet J. 2009 May;180(2):149-62
pubmed: 18786842
J Comp Pathol. 2003 Jul;129(1):78-84
pubmed: 12859911
Differentiation. 2001 Oct;68(4-5):270-9
pubmed: 11776479
Vet Pathol. 2004 Mar;41(2):131-40
pubmed: 15017026
Vet Pathol. 2017 May;54(3):380-386
pubmed: 27879443
Hum Pathol. 2014 Aug;45(8):1572-81
pubmed: 24842280
Am J Surg Pathol. 1998 Jul;22(7):840-8
pubmed: 9669346
Am J Surg Pathol. 2016 Jun;40(6):e67-82
pubmed: 26848801
Virchows Arch. 2019 May;474(5):525-534
pubmed: 30825003
Hum Pathol. 2002 Nov;33(11):1136-40
pubmed: 12454820
Vet Comp Oncol. 2022 Mar;20(1):38-49
pubmed: 33963663
Mod Pathol. 2006 Dec;19(12):1528-35
pubmed: 16980940
PLoS One. 2018 Jun 12;13(6):e0199173
pubmed: 29894516
Semin Diagn Pathol. 2005 Feb;22(1):88-104
pubmed: 16512601
Cancer. 2002 Sep 1;95(5):1028-36
pubmed: 12209687
Vet Pathol. 2015 Nov;52(6):1027-33
pubmed: 25755134
Hum Pathol. 1996 Jul;27(7):683-7
pubmed: 8698312
Vet Pathol. 2018 Mar;55(2):224-232
pubmed: 29262763
J Vet Intern Med. 1987 Oct-Dec;1(4):183-7
pubmed: 3506104
Appl Immunohistochem Mol Morphol. 2011 Oct;19(5):395-9
pubmed: 21617524
Prostate. 2002 May 1;51(2):117-25
pubmed: 11948966
Vet Comp Oncol. 2016 Dec;14(4):337-349
pubmed: 25059752
Hum Pathol. 2012 Mar;43(3):313-24
pubmed: 22325142
Nat Rev Urol. 2018 Jan;15(1):11-24
pubmed: 29089606
J Urol. 1994 May;151(5):1427-32
pubmed: 8158800
Am J Pathol. 2000 Dec;157(6):1769-75
pubmed: 11106548
Vet Comp Oncol. 2016 Sep;14(3):263-9
pubmed: 24758385
J Comp Pathol. 2019 Aug;171:30-37
pubmed: 31540623
Am J Surg Pathol. 2007 Aug;31(8):1246-55
pubmed: 17667550
Prostate. 2008 Apr 1;68(5):477-88
pubmed: 18196537
Appl Immunohistochem Mol Morphol. 2015 Nov-Dec;23(10):711-6
pubmed: 25611245
Am J Surg Pathol. 2012 Oct;36(10):1472-6
pubmed: 22982890
Nat Med. 2016 Mar;22(3):298-305
pubmed: 26855148
Mol Cell Endocrinol. 2002 Nov 29;197(1-2):251-5
pubmed: 12431819
Cancer Res. 2013 May 1;73(9):2718-36
pubmed: 23610450
ScientificWorldJournal. 2012;2012:252034
pubmed: 22919300
Int J Surg Pathol. 2019 Apr;27(2):120-133
pubmed: 30509113
Am J Surg Pathol. 2003 Jan;27(1):1-10
pubmed: 12502922
Virchows Arch. 2011 Mar;458(3):301-12
pubmed: 21136076
Eur Urol. 2004 May;45(5):586-92; discussion 592
pubmed: 15082200
Vet Pathol. 2003 Jan;40(1):55-62
pubmed: 12627713
Prostate. 2001 Aug 1;48(3):210-24
pubmed: 11494337
Endocr Relat Cancer. 2007 Sep;14(3):531-47
pubmed: 17914087
Prostate. 1998 Jun 15;36(1):64-7
pubmed: 9650919
Hum Pathol. 2013 Feb;44(2):164-72
pubmed: 22995333
Am J Surg Pathol. 2014 Aug;38(8):1017-22
pubmed: 25025364
APMIS. 2015 Sep;123(9):772-8
pubmed: 26200506
Vet Pathol. 2015 Jul;52(4):614-20
pubmed: 25248518
Vet Comp Oncol. 2004 Mar;2(1):13-23
pubmed: 19379307
Oncol Lett. 2018 Aug;16(2):1641-1649
pubmed: 30008848
Am J Clin Pathol. 2000 May;113(5):683-7
pubmed: 10800401
Cell Death Differ. 1999 Dec;6(12):1169-73
pubmed: 10637432
Diagn Pathol. 2011 Jul 21;6:67
pubmed: 21777423
Nat Med. 2017 Jun 6;23(6):1-10
pubmed: 28586335
Diagn Pathol. 2012 Jul 16;7:81
pubmed: 22800084
Am J Clin Pathol. 2001 Dec;116(6):823-30
pubmed: 11764070
Eur Urol. 2016 Jul;70(1):106-119
pubmed: 26996659
Vet Comp Oncol. 2019 Sep;17(3):298-307
pubmed: 30767361
Vet Pathol. 2018 Jul;55(4):501-509
pubmed: 29444629
Diagn Pathol. 2011 May 31;6:46
pubmed: 21627811
Cancer. 1968 Dec;22(6):1329-45
pubmed: 5750856
J Vet Diagn Invest. 2008 Nov;20(6):766-73
pubmed: 18987226
Vet Comp Oncol. 2018 Dec;16(4):450-458
pubmed: 29806232