Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies.

Breast Neoplasms / prevention & control Calcium / administration & dosage Cohort Studies Dairy Products Female Humans Multivariate Analysis Receptors, Estrogen / genetics Risk Factors
breast cancer calcium cheese dairy products diet milk pooled analysis yogurt

Journal

The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027

Informations de publication

Date de publication:
02 08 2021
Historique:
received: 01 12 2020
accepted: 05 03 2021
pubmed: 9 5 2021
medline: 2 9 2021
entrez: 8 5 2021
Statut: ppublish

Résumé

Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes. To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status. We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Associations were evaluated for dairy product and calcium intakes and risk of incident invasive breast cancer overall (n = 37,861 cases) and by subtypes defined by ER status. Study-specific multivariable hazard ratios (HRs) were estimated and then combined using random-effects models. Overall, no clear association was observed between the consumption of specific dairy foods, dietary (from foods only) calcium, and total (from foods and supplements) calcium, and risk of overall breast cancer. Although each dairy product showed a null or very weak inverse association with risk of overall breast cancer (P, test for trend >0.05 for all), differences by ER status were suggested for yogurt and cottage/ricotta cheese with associations observed for ER-negative tumors only (pooled HR = 0.90, 95% CI: 0.83, 0.98 comparing ≥60 g/d with <1 g/d of yogurt and 0.85, 95% CI: 0.76, 0.95 comparing ≥25 g/d with <1 g/d of cottage/ricotta cheese). Dietary calcium intake was only weakly associated with breast cancer risk (pooled HR = 0.98, 95% CI: 0.97, 0.99 per 350 mg/d). Our study shows that adult dairy or calcium consumption is unlikely to associate with a higher risk of breast cancer and that higher yogurt and cottage/ricotta cheese intakes were inversely associated with the risk of ER-negative breast cancer, a less hormonally dependent subtype with poor prognosis. Future studies on fermented dairy products, earlier life exposures, ER-negative breast cancer, and different racial/ethnic populations may further elucidate the relation.

Sections du résumé

BACKGROUND
Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes.
OBJECTIVE
To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status.
METHOD
We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Associations were evaluated for dairy product and calcium intakes and risk of incident invasive breast cancer overall (n = 37,861 cases) and by subtypes defined by ER status. Study-specific multivariable hazard ratios (HRs) were estimated and then combined using random-effects models.
RESULTS
Overall, no clear association was observed between the consumption of specific dairy foods, dietary (from foods only) calcium, and total (from foods and supplements) calcium, and risk of overall breast cancer. Although each dairy product showed a null or very weak inverse association with risk of overall breast cancer (P, test for trend >0.05 for all), differences by ER status were suggested for yogurt and cottage/ricotta cheese with associations observed for ER-negative tumors only (pooled HR = 0.90, 95% CI: 0.83, 0.98 comparing ≥60 g/d with <1 g/d of yogurt and 0.85, 95% CI: 0.76, 0.95 comparing ≥25 g/d with <1 g/d of cottage/ricotta cheese). Dietary calcium intake was only weakly associated with breast cancer risk (pooled HR = 0.98, 95% CI: 0.97, 0.99 per 350 mg/d).
CONCLUSION
Our study shows that adult dairy or calcium consumption is unlikely to associate with a higher risk of breast cancer and that higher yogurt and cottage/ricotta cheese intakes were inversely associated with the risk of ER-negative breast cancer, a less hormonally dependent subtype with poor prognosis. Future studies on fermented dairy products, earlier life exposures, ER-negative breast cancer, and different racial/ethnic populations may further elucidate the relation.

Identifiants

DOI: 10.1093/ajcn/nqab097 PMID: 33964859 PMC: PMC8326053
pubmed: 33964859
pii: S0002-9165(22)00361-6
doi: 10.1093/ajcn/nqab097
pmc: PMC8326053
doi:

Substances chimiques

Receptors, Estrogen 0
Calcium SY7Q814VUP

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

450-461

Subventions

Organisme : NCI NIH HHS
ID : K01 CA212056
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA055075
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167462
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182934
Pays : United States

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

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Auteurs

You Wu (Y)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Ruyi Huang (R)

Department of Medical Education, E-DA Hospital and School of Medicine for International Students, School of Medicine, I-SHOU University, Kaohsiung City, Taiwan.
Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
ORCID: 0000-0001-6867-7171

Molin Wang (M)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Leslie Bernstein (L)

Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
ORCID: 0000-0002-7692-6518

Traci N Bethea (TN)

Slone Epidemiology Center at Boston University, Boston, MA, USA.
Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Chu Chen (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Yu Chen (Y)

Division of Epidemiology, Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

A Heather Eliassen (AH)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Neal D Freedman (ND)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Mia M Gaudet (MM)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Gretchen L Gierach (GL)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Vittorio Krogh (V)

Epidemiology and Prevention Unit Department of Research, IRCCS National Cancer Institute Foundation, Milan, Italy.
ORCID: 0000-0003-0122-8624

Susanna C Larsson (SC)

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
ORCID: 0000-0003-0118-0341

Linda M Liao (LM)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Marjorie L McCullough (ML)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Anthony B Miller (AB)

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Kristine R Monroe (KR)

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Marian L Neuhouser (ML)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Julie R Palmer (JR)

Slone Epidemiology Center at Boston University, Boston, MA, USA.
Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Anna Prizment (A)

Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Peggy Reynolds (P)

Department of Epidemiology and Biostatistics, University of California San Francisco, Berkeley, CA, USA.

Kim Robien (K)

Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, WA, USA.

Thomas E Rohan (TE)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Sven Sandin (S)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seaver Autism Center for Research and Treatment at Mount Sinai, New York, NY, USA.

Norie Sawada (N)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
ORCID: 0000-0002-9936-1476

Sabina Sieri (S)

Epidemiology and Prevention Unit Department of Research, IRCCS National Cancer Institute Foundation, Milan, Italy.
ORCID: 0000-0001-5201-172X

Rashmi Sinha (R)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Rachael Z Stolzenberg-Solomon (RZ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Shoichiro Tsugane (S)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
ORCID: 0000-0003-4105-2774

Piet A van den Brandt (PA)

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Department of Epidemiology, Care and Public Health Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Kala Visvanathan (K)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0002-0582-8005

Elisabete Weiderpass (E)

International Agency for Research on Cancer, WHO, Lyon, France.
ORCID: 0000-0003-2237-0128

Lynne R Wilkens (LR)

University of Hawaii Cancer Center, Honolulu, HI, USA.

Walter C Willett (WC)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Alicja Wolk (A)

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

Anne Zeleniuch-Jacquotte (A)

Division of Epidemiology, Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

Regina G Ziegler (RG)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Stephanie A Smith-Warner (SA)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Aliments et boissons › Aliments › Produits laitiers › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de variance › Analyse multifactorielle › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Dairy foods, calcium, and risk of breast...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Dairy foods, calcium, and risk of breast...