Effect of varicoceles on spermatogenesis.

Humans Infertility, Male / physiopathology Male Spermatogenesis / physiology Testosterone / deficiency Varicocele / complications
Male infertility Oxidative stress Spermatogenesis Testicular dysfunction Testosterone deficiency Varicocele

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
01 2022
Historique:
received: 21 12 2020
accepted: 05 04 2021
pubmed: 10 5 2021
medline: 11 3 2022
entrez: 9 5 2021
Statut: ppublish

Résumé

Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptomatic, however, a proportion of men with varicoceles can suffer from infertility and testosterone deficiency. Sperm and testosterone are produced within the testis, and any alteration to the testicular environment can negatively affect the cells responsible for these processes. The negative impact of varicoceles on testicular function occurs mainly due to increased oxidative stress within the testicular parenchyma which is thought to be caused by scrotal hyperthermia, testicular hypoxia, and blood-testis barrier disruption. Management of varicoceles involves ligation or percutaneous embolization of the dilated veins. Repair of varicoceles can improve semen parameters and fertility, along with serum testosterone concentration. In this review, we discuss the pathophysiology of varicoceles, their impact on testicular function, and management.

Identifiants

DOI: 10.1016/j.semcdb.2021.04.005 PMID: 33965333
pubmed: 33965333
pii: S1084-9521(21)00078-1
doi: 10.1016/j.semcdb.2021.04.005
pii:
doi:

Substances chimiques

Testosterone 3XMK78S47O

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114-124

Informations de copyright

Copyright © 2021. Published by Elsevier Ltd.

Auteurs

Caroline Kang (C)

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address: cak4005@med.cornell.edu.

Nahid Punjani (N)

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address: nap4001@med.cornell.edu.

Richard K Lee (RK)

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address: ril9010@med.cornell.edu.

Philip S Li (PS)

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address: psli@med.cornell.edu.

Marc Goldstein (M)

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address: mgoldst@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of varicoceles on spermatogenesis.
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Infertilité masculine › Effect of varicoceles on spermatogenesis.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Gamétogenèse › Spermatogenèse › Effect of varicoceles on spermatogenesis.
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Effect of varicoceles on spermatogenesis.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Varicocèle › Effect of varicoceles on spermatogenesis.