Lateral habenula cannabinoid CB1 receptor involvement in drug-associated impulsive behavior.
Animals
Choice Behavior
/ drug effects
Cocaine
/ administration & dosage
Dose-Response Relationship, Drug
Dronabinol
/ pharmacology
Habenula
/ drug effects
Impulsive Behavior
/ drug effects
Male
Rats
Rats, Long-Evans
Reaction Time
/ drug effects
Receptor, Cannabinoid, CB1
/ agonists
Self Administration
Addiction
Cannabinoids
Cocaine
Habenula
Impulsivity
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
22
01
2021
revised:
29
04
2021
accepted:
01
05
2021
pubmed:
10
5
2021
medline:
17
12
2021
entrez:
9
5
2021
Statut:
ppublish
Résumé
Animal and human studies show that cannabis or its derivatives can increase relapse to cocaine seeking following withdrawal. Moreover, cannabis use in humans is associated with impulse control deficits and animal studies implicate endogenous cannabinoids (eCB) in several impulsivity constructs. However, the brain areas where cannabinoids might control impulsivity or cocaine seeking are largely unknown. Here, we assess Lateral Habenula (LHb) involvement on performance in the 5-choice serial reaction time task (5CSRTT) in rats and investigate whether LHb cannabinoid CB1 receptors (CB1R) are involved in these effects. Systemic cocaine increased premature responding, a measure of impulsivity, at a dose (5 mg/kg) that did not alter other measures of task performance. Intra-LHb infusion of the CB1R antagonist AM251 blocked this effect. Systemic injection of the psychoactive constituent of cannabis, Δ
Identifiants
pubmed: 33965396
pii: S0028-3908(21)00158-1
doi: 10.1016/j.neuropharm.2021.108604
pmc: PMC8217315
mid: NIHMS1705298
pii:
doi:
Substances chimiques
Receptor, Cannabinoid, CB1
0
Dronabinol
7J8897W37S
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
108604Subventions
Organisme : Intramural NIH HHS
ID : Z01 DA000457
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DA000487
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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