Low income and outcome in idiopathic pulmonary fibrosis: An association to uncover.

Biosimilar Pharmaceuticals Disease-Free Survival Environmental Exposure / adverse effects France Idiopathic Pulmonary Fibrosis / economics Income / classification Occupational Exposure / adverse effects Particulate Matter / adverse effects Poverty Prognosis Proportional Hazards Models Prospective Studies Vital Capacity
Air pollution Idiopathic pulmonary fibrosis Income Occupational exposure Socioeconomic status

Journal

Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438

Informations de publication

Date de publication:
07 2021
Historique:
received: 03 02 2021
revised: 22 03 2021
accepted: 12 04 2021
pubmed: 10 5 2021
medline: 28 12 2021
entrez: 9 5 2021
Statut: ppublish

Résumé

Low income, a known prognostic indicator of various chronic respiratory diseases, has not been properly studied in idiopathic pulmonary fibrosis (IPF). We hypothesize that a low income has an adverse prognostic impact on IPF. Patients were selected from the French national prospective cohort COFI. Patients' income was assessed through the median city-level income provided by the French National Institute of Statistics and Economic Studies according to their residential address. Patients were classified in two groups as "low income" vs. "higher income" depending on whether their annual income was estimated to be < or ≥18 170 €/year (the first quartile of the income distribution in the study population). The survival and progression-free survival (PFS) of the groups were compared by a log-rank test and a Cox model in multivariate analysis. 200 patients were included. The average follow-up was 33.8 ± 22.7 months. Patients in the low income group were significantly more likely to be of non-European origin (p < 0.006), and to have at least one occupational exposure (p < 0.0001), and they tended to have a higher cumulative exposure to fine particles PM Low income appears to be a prognostic factor in IPF. IPF patients with low incomes may also be exposed more frequently to occupational exposures.

Sections du résumé

BACKGROUND
Low income, a known prognostic indicator of various chronic respiratory diseases, has not been properly studied in idiopathic pulmonary fibrosis (IPF). We hypothesize that a low income has an adverse prognostic impact on IPF.
METHODS
Patients were selected from the French national prospective cohort COFI. Patients' income was assessed through the median city-level income provided by the French National Institute of Statistics and Economic Studies according to their residential address. Patients were classified in two groups as "low income" vs. "higher income" depending on whether their annual income was estimated to be < or ≥18 170 €/year (the first quartile of the income distribution in the study population). The survival and progression-free survival (PFS) of the groups were compared by a log-rank test and a Cox model in multivariate analysis.
RESULTS
200 patients were included. The average follow-up was 33.8 ± 22.7 months. Patients in the low income group were significantly more likely to be of non-European origin (p < 0.006), and to have at least one occupational exposure (p < 0.0001), and they tended to have a higher cumulative exposure to fine particles PM
CONCLUSIONS
Low income appears to be a prognostic factor in IPF. IPF patients with low incomes may also be exposed more frequently to occupational exposures.

Identifiants

DOI: 10.1016/j.rmed.2021.106415 PMID: 33965849
pubmed: 33965849
pii: S0954-6111(21)00121-9
doi: 10.1016/j.rmed.2021.106415
pii:
doi:

Substances chimiques

Biosimilar Pharmaceuticals 0
Particulate Matter 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106415

Investigateurs

Diane Bouvry (D)
Pierre Yves Brillet (PY)
Philippe Camus (P)
Juliette Chabrol (J)
Jean François Cordier (JF)
Christophe Cracco (C)
Philippe Delaval (P)
Morgane Didier (M)
Boris Duchemann (B)
Sevrine Feuillet (S)
Olivia Freynet (O)
Frédéric Gagnadoux (F)
Patrick Germaud (P)
Louise Gindre (L)
André Guetta (A)
Patrick Haussman (P)
Stephane Jouneau (S)
Marianne Kambouchner (M)
Chahera Khouatra (C)
Jacques Lacronique (J)
Anita Molard (A)
Clément Picard (C)
Carole Planes (C)
Paul Andrés Rosental (PA)
Olivier Sanchez (O)
Thomas Similowski (T)
Luc Thiberville (L)
Yurdagül Uzuhnan (Y)

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Lucile Sesé (L)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France; AP-HP, Service de Physiologie, Hôpital Avicenne, Bobigny, France; Université Sorbonne Paris Nord, INSERM, 1272, « Hypoxie et Poumon: Pneumopathies Fibrosantes, Modulations Ventilatoires et Circulatoires », Bobigny, France; EPAR, IPLESP UMR-S, 1136, INSERM et Sorbonne Université, Paris, France.

Julien Caliez (J)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France.

Isabella Annesi-Maesano (I)

Institut Desbrest d'Epidémiologie et Santé Publique (IDESP), INSERM et Université de Montpellier, Montpellier, France.

Vincent Cottin (V)

Centre de Référence des Maladies Pulmonaires Rares (site Coordonnateur), Hôpital Louis Pradel, Hospices Civils de Lyon, Université Lyon 1, Université de Lyon, INRAE, OrphaLung; Member of Respifil; ERN-LUNG, Lyon, France.

Giancarlo Pesce (G)

EPAR, IPLESP UMR-S, 1136, INSERM et Sorbonne Université, Paris, France.

Morgane Didier (M)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France.

Zohra Carton (Z)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France.

Dominique Israel-Biet (D)

Centre de Compétence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital HEGP, Paris, France.

Bruno Crestani (B)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Bichat, Paris, France.

Stéphanie Guillot Dudoret (SG)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Pontchaillou, Rennes, France.

Jacques Cadranel (J)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Tenon and Sorbonne University, Paris, France.

Benoit Wallaert (B)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), Service de Pneumologie, Hôpital Albert Calmette, Lille, France.

Abdellatif Tazi (A)

Université de Paris, F-75006, Paris, Centre de Référence National des Histiocytose, AP-HP, Service de Pneumologie, Hôpital Saint-Louis, Paris, France.

Bernard Maître (B)

AP-HP, Service de Pneumologie, Hôpital Henri Mondor, Université Paris Est, INSERM U955, 94 000, Créteil, France.

Grégoire Prévot (G)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Larrey, Toulouse, France.

Sylvain Marchand-Adam (S)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Bretonneau, Tours, France.

Sandrine Hirschi (S)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Nouvel Hôpital Civil, Strasbourg, France.

Sandra Dury (S)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Maison Blanche, Reims, France.

Violaine Giraud (V)

AP-HP, Service de Pneumologie, Hôpital Ambroise Paré, Boulogne, France.

Anne Gondouin (A)

Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Jean Minjoz, Besançon, France.

Philippe Bonniaud (P)

Centre Référence des Maladies Pulmonaires Rares (site Constitutif), Service de Pneumologie, Centre Hospitalier Universitaire Dijon Bourgogne, Dijon, France.

Julie Traclet (J)

Centre de Référence des Maladies Pulmonaires Rares (site Coordonnateur), Hôpital Louis Pradel, Hospices Civils de Lyon, Université Lyon 1, Université de Lyon, INRAE, OrphaLung; Member of Respifil; ERN-LUNG, Lyon, France.

Karine Juvin (K)

Centre de Compétence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital HEGP, Paris, France.

Raphael Borie (R)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Bichat, Paris, France.

Jean François Bernaudin (JF)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France; EPAR, IPLESP UMR-S, 1136, INSERM et Sorbonne Université, Paris, France.

Dominique Valeyre (D)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France; Université Sorbonne Paris Nord, INSERM, 1272, « Hypoxie et Poumon: Pneumopathies Fibrosantes, Modulations Ventilatoires et Circulatoires », Bobigny, France.

Catherine Cavalin (C)

Institut de Recherche Interdisciplinaire en Sciences Sociales (IRISSO, UMR CNRS-INRAE 7170-1427), Paris-Dauphine Université, PSL, Paris, France; Laboratoire Interdisciplinaire D'évaluation des Politiques Publiques de Sciences Po (LIEPP), Sciences Po, Paris, France.

Hilario Nunes (H)

Centre de Référence des Maladies Pulmonaires Rares (site Constitutif), AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France; Université Sorbonne Paris Nord, INSERM, 1272, « Hypoxie et Poumon: Pneumopathies Fibrosantes, Modulations Ventilatoires et Circulatoires », Bobigny, France. Electronic address: hilario.nunes@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Produits pharmaceutiques biosimilaires › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Régions géographiques › Europe › France › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Fibrose pulmonaire idiopathique › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Revenu › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Pauvreté › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Diagnostic › Pronostic › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Low income and outcome in idiopathic pulmonary...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Capacité pulmonaire totale › Capacité vitale › Low income and outcome in idiopathic pulmonary...