Effect of Delayed Cord Clamping on Neurodevelopment at 3 Years: A Randomized Controlled Trial.
Ages and Stages Questionnaire
Child
Delayed cord clamping
Neurodevelopment
Umbilical cord
Journal
Neonatology
ISSN: 1661-7819
Titre abrégé: Neonatology
Pays: Switzerland
ID NLM: 101286577
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
11
2020
accepted:
25
02
2021
pubmed:
10
5
2021
medline:
1
9
2021
entrez:
9
5
2021
Statut:
ppublish
Résumé
Iron deficiency (ID) is associated with poor neurodevelopment. We have previously shown that delayed umbilical cord clamping (CC) improves iron stores at 8 months and neurodevelopment at 1 year in term, healthy infants in Nepal. The aim of this study was to assess the effects of delayed CC (≥180 s) compared to early CC (≤60 s) on neurodevelopment using the Ages and Stages Questionnaire (ASQ) at age 3 years. In 2014, 540 healthy Nepalese infants born at term were randomized in a 1:1 ratio to delayed or early CC. At 3 years of age, ASQ assessment was performed by phone interviews with parents. A score >1 standard deviation below the mean was defined as "at risk" for developmental impairment. At 3 years of age, 350 children were followed up, 170 (63.0%) in the early CC group and 180 (66.7%) in the delayed CC group. No significant differences in ASQ scores in any domains between groups were found. However, more girls were "at risk" for affected gross motor development in the early CC group: 14 (18.9%) versus 6 (6.3%), p = 0.02. There were no significant differences in ASQ scores in any domains between groups. In the subgroup analysis, fewer girls who underwent delayed CC were "at risk" for delayed gross motor development. Due to the pronounced difference in iron stores at 8 months postpartum in this cohort, follow-up studies at an older age are motivated since neurodevelopmental impairment after early ID may be more detectable with increasing age.
Identifiants
pubmed: 33965945
pii: 000515838
doi: 10.1159/000515838
pmc: PMC8491483
doi:
Banques de données
ClinicalTrials.gov
['NCT02222805']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
282-288Informations de copyright
© 2021 The Author(s) Published by S. Karger AG, Basel.
Références
Nutrients. 2019 Aug 03;11(8):
pubmed: 31382653
Lancet. 1969 Oct 25;2(7626):871-3
pubmed: 4186454
Public Health Nutr. 2009 Apr;12(4):444-54
pubmed: 18498676
JAMA Pediatr. 2017 Mar 1;171(3):264-270
pubmed: 28114607
Early Hum Dev. 2015 Mar;91(3):217-25
pubmed: 25703316
Am J Perinatol. 2020 Jul 21;:
pubmed: 32702760
Arch Dis Child. 2019 Apr;104(Suppl 1):S22-S33
pubmed: 30885963
J Pediatr Psychol. 1997 Jun;22(3):313-28
pubmed: 9212550
Dev Psychopathol. 2015 May;27(2):411-23
pubmed: 25997762
Nutr Rev. 2011 Nov;69 Suppl 1:S43-8
pubmed: 22043882
Cardiol Young. 2017 Oct;27(8):1447-1454
pubmed: 28376931
JAMA Pediatr. 2014 Jun;168(6):547-54
pubmed: 24756128
J Pediatr. 2018 Dec;203:266-272.e2
pubmed: 30473033
JAMA Pediatr. 2015 Jul;169(7):631-8
pubmed: 26010418
Early Hum Dev. 2017 Dec;115:99-109
pubmed: 29049945
Matern Child Health J. 2020 Feb;24(Suppl 1):5-14
pubmed: 31773465
Acta Paediatr. 2013 May;102(5):525-31
pubmed: 23336628
Neonatology. 2019;115(1):36-42
pubmed: 30278462
Cochrane Database Syst Rev. 2013 Jul 11;(7):CD004074
pubmed: 23843134
Dev Med Child Neurol. 2019 Apr;61(4):431-443
pubmed: 29926467
BMJ. 2011 Nov 15;343:d7157
pubmed: 22089242
J Perinatol. 2010 Jan;30(1):11-6
pubmed: 19847185
Neonatology. 2016;109(2):113-9
pubmed: 26650133
J Pediatr. 2016 Jan;168:50-55.e1
pubmed: 26547399
Acta Paediatr. 2021 Feb;110(2):465-472
pubmed: 32506539