Exploring the Interplay Between Radiotherapy Dose and Physiological Changes in the Swallowing Mechanism in Patients Undergoing (Chemo)radiotherapy for Oropharynx Cancer.
DARS
Dysphagia
Physiology
Radiotherapy
Swallow
Journal
Dysphagia
ISSN: 1432-0460
Titre abrégé: Dysphagia
Pays: United States
ID NLM: 8610856
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
31
07
2020
accepted:
20
04
2021
pubmed:
10
5
2021
medline:
10
5
2022
entrez:
9
5
2021
Statut:
ppublish
Résumé
This study explored associative relationships between radiotherapy dose volumes delivered to the dysphagia aspiration risk structures (DARS) and swallowing physiological disturbance at 3 months post treatment in a homogenous cohort of patients who received (chemo)radiotherapy ((C)RT) for oropharyngeal head and neck cancer (HNC). Participants(n = 53) were a subgroup of patients previously recruited as part of a prospective randomised trial, and had undergone physiological swallowing assessment using videofluroscopic swallowing study (VFSS) at 3 months post (C)RT. The extended oral cavity (EOC), supraglottic larynx (SGL), glottic larynx (GL), cricopharyngeal inlet (CI), and pharyngeal constrictor muscles (PCM) were contoured as per international consensus guidelines and dose volume histograms (DVHs) were generated for each structure. Each DVH was analysed to reveal mean, maximum and partial radiotherapy doses of V
Identifiants
pubmed: 33966115
doi: 10.1007/s00455-021-10307-2
pii: 10.1007/s00455-021-10307-2
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-577Informations de copyright
© 2021. Crown.
Références
Adelstein DJ. Concurrent chemoradiotherapy in the management of squamous cell cancer of the oropharynx: current standards and future directions. Int J Radiat Oncol. 2007;69:S37-39. https://doi.org/10.1016/j.ijrobp.2007.04.086 .
doi: 10.1016/j.ijrobp.2007.04.086
Schuttrumpf L, Marschner S, Scheu K, Hess J, Rietzler S, Walch A, Baumeister P, Kirchner T, Ganswindt U, Zitzelsberger H, Belka C, Maihoefer C. Definitive chemoradiotherapy in patients with squamous cell cancers of the head and neck–results from an unselected cohort of the clinical cooperation group “Personalised Radiotherapy in Head and Neck Cancer.” Radiother Oncol. 2020. https://doi.org/10.1186/s13014-019-1452-4 .
doi: 10.1186/s13014-019-1452-4
Lavertu P, Adelstein DJ, Saxton JP, Secic M, Eliachar I, Strome M, Larto MA, Wood BG. Aggressive concurrent chemoradiotherapy for squamous cell head and neck cancer: an 8-year single-institution experience. Otolaryng Head Neck. 1999;125:142–8. https://doi.org/10.1001/archotol.125.2.142 .
doi: 10.1001/archotol.125.2.142
Fenwick JD, Pardo-Montero J, Nahum AE, Malik ZI. Impact of schedule duration on head and neck radiotherapy: accelerated tumour repopulation versus compensatory mucosal proliferation. Int J Radiat Oncol. 2012;82:1021–30. https://doi.org/10.1016/j.ijrobp.2010.12.048 .
doi: 10.1016/j.ijrobp.2010.12.048
Bath SS, Caudell JJ, Chen AM. Practical considerations in reducing swallowing dysfunction following concurrent chemoradiotherapy with intensity- modulated radiotherapy for head and neck cancer. Head Neck. 2014;36:291–8. https://doi.org/10.1002/hed.23246 .
doi: 10.1002/hed.23246
King SN, Dunlap NE, Tennant PA, Pitts T. Pathophysiology of radiation-induced dysphagia in head and neck cancer. Dysphagia. 2016;31:339–51. https://doi.org/10.1007/s00455-016-9710-1 .
doi: 10.1007/s00455-016-9710-1
pubmed: 27098922
pmcid: 5340192
Roe JW, Carding PN, Dwivedi RC, Kazi RA, Rhys-Evans PH, Harrington KJ, Nutting CM. Swallowing outcomes following intensity modulated radiation therapy (IMRT) for head & neck cancer—a systematic review. Oral Oncol. 2010;46:727–33. https://doi.org/10.1016/j.oraloncology.2010.07.012 .
doi: 10.1016/j.oraloncology.2010.07.012
pubmed: 20850370
Cartmill B, Ward EC, MacGinley O, Porceddu SV (2016) Oral health, dysphagia, distress and health service needs of head and neck cancer survivors 5 years post-chemoradiotherapy. Int J Oral Dent Health. https://doi.org/10.23937/2469-5734/1510024 .
Aylward A, Abdelaziz S, Hunt JP, Buchmann LO, Cannon RB, Lloyd S, Hitchcock Y, Hashibe M, Monroe MM. Rates of dysphagia-related diagnoses in long-term survivors of head and neck cancers. Otolaryng Head Neck. 2019;161:643–51. https://doi.org/10.1177/0194599819850154 .
doi: 10.1177/0194599819850154
Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Gaziano J, Stachowiak L, Newman L, MacCracken E, Santa D, Mittal B. Swallowing disorders in the first year after radiation and chemoradiation. Head Neck. 2008;30:148–58. https://doi.org/10.1002/hed.20672 .
doi: 10.1002/hed.20672
pubmed: 17786992
pmcid: 2903205
Logemann JA, Rademaker AW, Pauloski BR, Lazarus CL, Mittal BB, Brockstein B, MacCracken E, Haraf DJ, Vokes EE, Newman LA, Liu D. Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck. 2006;28:64–73. https://doi.org/10.1002/hed.20299 .
doi: 10.1002/hed.20299
pubmed: 16302193
pmcid: 1380204
Pauloski BR, Rademaker AW, Logemann JA, Lundy D, Berstein M, McBreen C, Santa D, Campanelli A, Kelchner L, Klaben B, Discekici-Harris M. Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer. Head Neck. 2011;33:774–9. https://doi.org/10.1002/hed.21542 .
doi: 10.1002/hed.21542
pubmed: 20737496
Rademaker AW, Vonesh EF, Logemann JA, Pauloski BR, Liu D, Lazarus CL, Newman LA, Hammer A, MacCracken E, Gaziano J, Stachowiak L. Eating ability in head and neck cancer patients after treatment with chemoradiation: a 12-month follow-up study. Head Neck. 2003;25:1034–41. https://doi.org/10.1002/hed.10317 .
doi: 10.1002/hed.10317
pubmed: 14648862
Wall LR, Ward EC, Cartmill B, Hill AJ. Physiological changes to the swallowing mechanism following (chemo)radiotherapy for head and neck cancer: a systematic review. Dysphagia. 2013;28:481–93. https://doi.org/10.1007/s00455-013-9491-8 .
doi: 10.1007/s00455-013-9491-8
pubmed: 24078216
van der Laan HP, Bijl HP, Steenbakkers RJ, van der Schaaf A, Chouvalova O, Vemer-van den Hoek JF, Gawryszuk A, van der Laan BF, Oosting SF, Roodenburg JL, Wopken K, Langendijk JA. Acute symptoms during the course of head and neck radiotherapy or chemoradiation are strong predictors of late dysphagia. Radiother Oncol. 2015;115:56–62. https://doi.org/10.1016/j.radonc.2015.01.019 .
doi: 10.1016/j.radonc.2015.01.019
pubmed: 25792467
Hutcheson KA. Late radiation-associated dysphagia (RAD) in head and neck cancer survivors. Perspectives on Swallowing and Swallowing Disorders (Dysphagia). 2013;22:61–72. https://doi.org/10.1016/j.oraloncology.2017.12.021 .
doi: 10.1016/j.oraloncology.2017.12.021
Hutcheson KA, Lewin JS, Barringer DA, Lisec A, Gunn GB, Moore MW, Holsinger FC. Late dysphagia after radiotherapy-based treatment of head and neck cancer. Cancer. 2012;118:5793–9. https://doi.org/10.1002/cncr.27631 .
doi: 10.1002/cncr.27631
pubmed: 23640737
Jensen K, Lambertsen K, Grau C. Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters. Radiother Oncol. 2007;85:74–82. https://doi.org/10.1016/j.radonc.2007.06.004 .
doi: 10.1016/j.radonc.2007.06.004
pubmed: 17673322
Nutting CM, Morden JP, Harrington KJ, Guerrero T, Bhide SA, Clark C, Miles EA, Miah AB, Newbold K, Tanay M, Adab F, Jefferies SJ, Scrase C, Yap BK, A’Hern RP, Syndenham MA, Emson M, Hall E. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PASSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011;12:127–36. https://doi.org/10.1016/S1470-2045(1)70290-4 .
doi: 10.1016/S1470-2045(1)70290-4
pubmed: 21236730
pmcid: 3033533
Eisbruch A, Schwartz M, Rasch C, Vineberg K, Damen E, Van As BCJ, Balm AJ. Dsyphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol. 2004;60:1425–39. https://doi.org/10.1016/j.ijrobp.2004.05.050 .
doi: 10.1016/j.ijrobp.2004.05.050
Levendag PC, Teguh DN, Voet P, van der Est H, Noever I, de Kruijf WJ, Kolkman-Deurloo IK, Hiejman BJ. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol. 2007;85:64–73. https://doi.org/10.1016/j.radonc.2007.07.009 .
doi: 10.1016/j.radonc.2007.07.009
pubmed: 17714815
Caudell JJ, Schaner PE, Desmond RA, Meredith RF, Spencer SA, Bonner JA. Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck. Int J Radiat Oncol. 2010;76:403–9. https://doi.org/10.1016/j.ijrobp.2009.02.017 .
doi: 10.1016/j.ijrobp.2009.02.017
Caglar HB, Tishler RB, Othus M, Burke E, Li Y, Goguen L, Wirth LJ, Norris CM, Court LE, Aninno DJ, Posner MR, Allan AM. Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol. 2008;72:1110–8. https://doi.org/10.1016/j.ijrobp.2008.02.048 .
doi: 10.1016/j.ijrobp.2008.02.048
Starmer HM, Quon H, Kumar R, Alcorn S, Murano E, Jones B, Humbert I. The effect of radiation dose on swallowing: evaluation of aspiration and kinematics. Dysphagia. 2015;30:430–7. https://doi.org/10.1007/s00455-015-9618-1 .
doi: 10.1007/s00455-015-9618-1
pubmed: 26025757
Schwartz DL, Hutcheson K, Barringer D, Tucker SL, Kies M, Holsinger FC, Ang KK, Morrison WH, Rosenthal DI, Garden AS, Dong L, Lewin JS. Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. Int J Radiat Oncol. 2010;78(5):1356–65. https://doi.org/10.1016/j.ijrobp.2009.10.002 .
doi: 10.1016/j.ijrobp.2009.10.002
Kumar R, Madanikia S, Starmer H, Yang W, Murano E, Alcorn S, McNutt T, Le Y, Quon H. Radiation dose to the floor of mouth muscles predicts swallowing complications following chemoradiation in oropharyngeal squamous cell carcinoma. Oral Oncol. 2014;50:65–70. https://doi.org/10.1016/j.oraloncology.2013.10.002 .
doi: 10.1016/j.oraloncology.2013.10.002
pubmed: 24238851
Duprez F, Madani I, De-Potter B, Boterberg T, De-Neve W. Systematic review of dose-volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer. Dysphagia. 2013;28:337–49. https://doi.org/10.1007/s00455-013-9452-2 .
doi: 10.1007/s00455-013-9452-2
pubmed: 23429941
Feng FY, Kim HM, Lyden TH, Haxer MJ, Feng M, Worden P, Chepeha DB, Eisbruch A. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2007;68:1289–98. https://doi.org/10.1016/j.ijrobp.2007.02.049 .
doi: 10.1016/j.ijrobp.2007.02.049
pubmed: 17560051
Feng FY, Kim HM, Lyden TH, Haxer MJ, Worden FP, Feng M, Moyer JS, Prince ME, Carey TE, Wolf GT, Bradford CR, Chepeha DB, Eisbruch A. Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results. J Clin Oncol. 2010;28:2732–8. https://doi.org/10.1200/JCO.2009.24.6199 .
doi: 10.1200/JCO.2009.24.6199
pubmed: 20421546
pmcid: 2881852
Amin N, Reddy K, Westerly D, Raben D, DeWitt P, Chen C. Sparing the larynx and esophageal inlet expedites feeding tube removal in patients with stage III-IV oropharyngeal squamous cell carcinoma treated with intensity-modulated radiotherapy. Laryngoscope. 2012;122:2736–42. https://doi.org/10.1002/lary.23597 .
doi: 10.1002/lary.23597
pubmed: 22991101
Roe JW, Carding PN, Dwivedi RC, Kazi RA, Rhys-Evans PH, Harrington KJ, Nutting CM. Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head & neck cancer - a systematic review. Oral Oncol. 2010;46:727–33. https://doi.org/10.1016/j.oraloncology.2010.07.012 .
doi: 10.1016/j.oraloncology.2010.07.012
pubmed: 20850370
Martin-Harris B, Brodsky MB, Michel Y, Castell DO, Schleicher M, Sandidge J, Maxwell R, Blair J. MBS measurement tool for swallow impairment—MBSImP: establishing a standard. Dysphagia. 2008;23:392–405. https://doi.org/10.1007/s00455-008-9185-9 .
doi: 10.1007/s00455-008-9185-9
pubmed: 18855050
pmcid: 4217120
Wall LR, Ward EC, Cartmill B, Hill AJ, Isenring E, Byrnes J, Porceddu SV. Prophylactic swallowing therapy for patients with head and neck cancer: a three-arm randomised parallel-group trial. Head Neck. 2020;42:873–85. https://doi.org/10.1002/hed.26060 .
doi: 10.1002/hed.26060
pubmed: 31903689
Philips. (n.d.). Radiation Oncology Treatment Planning Systems. https://www.philips.com.au/healthcare/solutions/radiation-oncology/radiation-treatment-planning
Brouwer CL, Steenbakkers RJ, Bourhis J, Budach E, Grau C, Gregoire V, van Herk M, Lee A, Maingon P, Nutting C, O’Sullivan B, Porceddu SV, Rosenthal DI, Sijtsema NM, Langendijk JA. CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines. Radiother Oncol. 2015;117:83–90. https://doi.org/10.1016/j.radonc.2015.07.041 .
doi: 10.1016/j.radonc.2015.07.041
pubmed: 26277855
Vinod SK, Jameson MG, Min M, Holloway LC. Uncertainties in volume delineation in radiation oncology: a systematic review and recommendations for future studies. Radiother Oncol. 2016;121:169–79. https://doi.org/10.1016/j.radonc.2016.09.009 .
doi: 10.1016/j.radonc.2016.09.009
pubmed: 27729166
Palma LF, Aurora F, Gonnelli S, Marcucci M, Giordani AJ, Dias RS, Segreto RA, Segreto HRC. A novel method to evaluate salivary flow rates of head and neck cancer patients after radiotherapy: a pilot study. Braz J Otorhinolaryngol. 2018;84:227–331. https://doi.org/10.1016/j.bjorl.2017.03.004 .
doi: 10.1016/j.bjorl.2017.03.004
pubmed: 28400176
Logemann, J.A. (Ed.). (1998). Evaluation and Treatment of Swallowing Disorders. Pro-Ed.
Petkar I, Rooney K, Roe JW, et al. DARS: a phase III randomised multicentre study of dysphagia- optimised intensity-modulated radiotherapy (Do-IMRT) versus standard intensity-modulated radiotherapy (S-IMRT) in head and neck cancer. BMC Cancer. 2016;16:770. https://doi.org/10.1186/s12885-016-2813-0 .
doi: 10.1186/s12885-016-2813-0
pubmed: 27716125
pmcid: 5052945