Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier.
Blood-brain barrier
Cerebral blood oxygen saturation
Loud sound
Mechanisms
Meningeal lymphatic clearance
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
9
5
2021
pubmed:
10
5
2021
medline:
12
5
2021
Statut:
ppublish
Résumé
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.
Identifiants
pubmed: 33966217
doi: 10.1007/978-3-030-48238-1_31
pmc: PMC9131853
mid: NIHMS1807053
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-202Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM109089
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112808
Pays : United States
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