Treatment with alitretinoin in patients taking part in a tertiary individual prevention program for work-related skin diseases.
alitretinoin
contact dermatitis
hand eczema
hyperkeratotic
occupational
prevention
tobacco smoking
vesicular
work-related
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
05
05
2021
received:
07
02
2021
accepted:
06
05
2021
pubmed:
10
5
2021
medline:
1
1
2022
entrez:
9
5
2021
Statut:
ppublish
Résumé
Patients taking part in a tertiary individual prevention program (TIP) for work-related skin diseases frequently have chronic hand eczema (HE) for which alitretinoin is a treatment option. To investigate treatment with alitretinoin before and during the TIP and related factors. Data of 1614 patients taking part in the TIP between January 2015 and December 2019 were analyzed retrospectively. Three hundred forty-eight patients (21.6%) reported treatment with alitretinoin prior to the TIP showing an increase over time, particularly in men. In 45 patients (2.8%), alitretinoin treatment was initiated during the TIP. Treatment with alitretinoin was significantly less common among female than male patients, both prior to (P < .001) and during the TIP (P = .015). Female patients who had received alitretinoin in the past were significantly older than the other female patients (P < .001). Among patients treated with alitretinoin prior to the TIP, women had a significantly higher disease severity at admission than men (P = .007). About twenty percent of patients reported treatment with alitretinoin prior to the TIP. The data indicate that treatment of female TIP patients with alitretinoin is less frequent than among male patients and depends on age and disease severity.
Sections du résumé
BACKGROUND
BACKGROUND
Patients taking part in a tertiary individual prevention program (TIP) for work-related skin diseases frequently have chronic hand eczema (HE) for which alitretinoin is a treatment option.
OBJECTIVE
OBJECTIVE
To investigate treatment with alitretinoin before and during the TIP and related factors.
METHODS
METHODS
Data of 1614 patients taking part in the TIP between January 2015 and December 2019 were analyzed retrospectively.
RESULTS
RESULTS
Three hundred forty-eight patients (21.6%) reported treatment with alitretinoin prior to the TIP showing an increase over time, particularly in men. In 45 patients (2.8%), alitretinoin treatment was initiated during the TIP. Treatment with alitretinoin was significantly less common among female than male patients, both prior to (P < .001) and during the TIP (P = .015). Female patients who had received alitretinoin in the past were significantly older than the other female patients (P < .001). Among patients treated with alitretinoin prior to the TIP, women had a significantly higher disease severity at admission than men (P = .007).
CONCLUSIONS
CONCLUSIONS
About twenty percent of patients reported treatment with alitretinoin prior to the TIP. The data indicate that treatment of female TIP patients with alitretinoin is less frequent than among male patients and depends on age and disease severity.
Substances chimiques
Dermatologic Agents
0
Alitretinoin
1UA8E65KDZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
446-453Informations de copyright
© 2021 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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