A North American prospective study of depression, psychotropic medication use, and semen quality.
Depression
psychotropic medications
semen analysis
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
13
11
2020
revised:
09
03
2021
accepted:
31
03
2021
pubmed:
11
5
2021
medline:
6
10
2021
entrez:
10
5
2021
Statut:
ppublish
Résumé
To evaluate the associations of a history of diagnosed depression, current depressive symptoms, and recent use of psychotropic medications with semen quality and to consider mediation of the association between depression and semen quality by medication use. Prospective cohort study. United States. The patients were 329 men aged ≥21 years (566 semen samples) who participated in a semen-testing substudy of Pregnancy Study Online. Pregnancy Study Online is an ongoing, web-based preconception cohort study of couples attempting to conceive. At baseline, participants reported information about depression diagnosis, depressive symptoms using the Major Depression Inventory, medication use in the last 4 weeks, and selected covariates. None. The men used an at-home semen-testing kit (Trak; Sandstone Diagnostics, Inc., Pleasanton, California) to measure semen volume, sperm concentration, and motile sperm concentration. We calculated percent motility, total sperm count in the ejaculate, and total motile sperm count. Forty-nine men (15%) reported a history of depression diagnosis, and 41 (12%) reported recent use of psychotropic medications. A history of depression diagnosis was associated with a 4.3-fold increase in the risk of low semen volume (<1.5 mL) (95% CI 1.16, 16). A 5-unit increase in Major Depression Inventory score was associated with a 1.38-fold increase in the risk of low semen volume (95% CI 0.92, 2.1). The results for other semen parameters were inconsistent. Recent use of psychotropic medications was associated with worse semen quality, and this association was confounded by a history of depression diagnosis. The observed association between depression and semen volume showed little mediation by psychotropic medication use. A history of diagnosed depression and severe depressive symptoms at enrollment were associated with low semen volume.
Identifiants
pubmed: 33966888
pii: S0015-0282(21)00263-6
doi: 10.1016/j.fertnstert.2021.03.052
pmc: PMC8410630
mid: NIHMS1691266
pii:
doi:
Substances chimiques
Psychotropic Drugs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
833-842Subventions
Organisme : NICHD NIH HHS
ID : K23 HD087428
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086742
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD105863
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD094322
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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