Gemcitabine maintenance therapy after gemcitabine and platinum drug chemotherapy for naive stage IIIB/IV squamous cell lung cancer: a phase II study.
Aged
Antineoplastic Agents
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Carcinoma, Squamous Cell
/ drug therapy
Cisplatin
/ administration & dosage
Deoxycytidine
/ administration & dosage
Drug Administration Schedule
Female
Humans
Lung Neoplasms
/ drug therapy
Male
Middle Aged
Neoplasm Staging
Progression-Free Survival
Gemcitabine
Journal
Anti-cancer drugs
ISSN: 1473-5741
Titre abrégé: Anticancer Drugs
Pays: England
ID NLM: 9100823
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
pubmed:
11
5
2021
medline:
8
1
2022
entrez:
10
5
2021
Statut:
ppublish
Résumé
Platinum doublet is the standard chemotherapy regimen for unresectable nonsmall-cell lung cancer (NSCLC) without a driver mutation. However, for squamous cell lung cancer, the most effective cytotoxic regimen is not yet established. Combination therapy of gemcitabine with a platinum agent is a highly effective treatment among the platinum doublet regimens and is promising as a treatment for advanced squamous cell lung carcinoma. In this study, we prospectively evaluated the efficacy of gemcitabine + platinum combination therapy followed by maintenance gemcitabine monotherapy in untreated advanced squamous cell lung cancer. Patients with squamous cell lung cancer received four cycles of gemcitabine + platinum combination therapy every 3 or 4 weeks. After the induction therapy, gemcitabine maintenance therapy was administered every 3 or 4 weeks until disease progression or unacceptable toxicity. Of 18 patients enrolled, the median progression-free survival was 3.9 months. Only six patients received maintenance chemotherapy with gemcitabine. The median survival time of all enrolled patients was 18.1 months. Cytopenia of any grade occurred in at least 70% of the enrolled patients. However, severe adverse events were observed in only a few cases. Gemcitabine maintenance therapy after gemcitabine plus platinum agents is a suggested treatment for unresectable squamous cell lung cancer. While the overall toxicity profile of this therapy is acceptable, attention should be paid to bone marrow suppression.
Identifiants
pubmed: 33967202
doi: 10.1097/CAD.0000000000001079
pii: 00001813-202109000-00013
doi:
Substances chimiques
Antineoplastic Agents
0
Deoxycytidine
0W860991D6
Cisplatin
Q20Q21Q62J
Gemcitabine
0
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
767-772Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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